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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DICER1
All Species:
14.85
Human Site:
Y1445
Identified Species:
25.13
UniProt:
Q9UPY3
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPY3
NP_085124.2
1922
218682
Y1445
Y
E
D
D
F
L
E
Y
D
Q
E
H
I
R
F
Chimpanzee
Pan troglodytes
XP_001154199
1922
218702
Y1445
Y
E
D
D
F
L
E
Y
D
Q
E
H
I
R
F
Rhesus Macaque
Macaca mulatta
XP_001100868
1920
218494
Y1443
Y
E
D
D
F
L
E
Y
D
Q
E
H
I
R
F
Dog
Lupus familis
XP_537547
1923
218622
Y1446
Y
E
D
D
F
L
E
Y
D
Q
E
H
I
K
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8R418
1916
216802
H1445
F
L
E
Y
D
Q
E
H
I
Q
F
I
D
S
M
Rat
Rattus norvegicus
XP_001068155
1918
216871
Q1445
D
D
L
L
E
Y
D
Q
E
H
I
Q
F
I
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510982
1921
218622
Q1446
D
D
F
L
E
Y
D
Q
E
H
I
K
F
I
D
Chicken
Gallus gallus
Q25BN1
1921
218592
Q1446
D
D
F
L
E
Y
D
Q
E
H
I
K
F
I
D
Frog
Xenopus laevis
NP_001163918
1795
204583
K1340
L
Y
R
L
G
K
K
K
G
S
P
S
R
M
V
Zebra Danio
Brachydanio rerio
Q6TV19
1865
210798
A1407
D
D
D
E
P
E
E
A
E
V
E
P
S
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCU9
2249
255312
R1649
L
N
A
D
W
V
A
R
H
E
Q
E
T
Y
N
Honey Bee
Apis mellifera
NP_001116485
1946
224489
S1444
R
L
E
T
I
G
D
S
F
L
K
Y
A
I
T
Nematode Worm
Caenorhab. elegans
P34529
1845
210905
K1359
T
I
G
D
S
F
L
K
F
A
T
T
D
Y
L
Sea Urchin
Strong. purpuratus
XP_790894
1850
210427
P1379
P
S
I
N
W
L
P
P
C
L
L
V
K
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.3
97
N.A.
93
93.5
N.A.
91.8
92
76.5
79.2
N.A.
27.7
35.8
31.7
43.5
Protein Similarity:
100
99.9
99.7
98.4
N.A.
96.1
96.4
N.A.
95.8
95.9
83.9
85.5
N.A.
44
54.5
49.6
60.7
P-Site Identity:
100
100
100
93.3
N.A.
13.3
0
N.A.
0
0
0
20
N.A.
6.6
0
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
33.3
20
N.A.
20
20
6.6
46.6
N.A.
33.3
26.6
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
8
8
0
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
29
29
36
43
8
0
29
0
29
0
0
0
15
0
22
% D
% Glu:
0
29
15
8
22
8
43
0
29
8
36
8
0
8
8
% E
% Phe:
8
0
15
0
29
8
0
0
15
0
8
0
22
0
29
% F
% Gly:
0
0
8
0
8
8
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
8
22
0
29
0
0
0
% H
% Ile:
0
8
8
0
8
0
0
0
8
0
22
8
29
29
0
% I
% Lys:
0
0
0
0
0
8
8
15
0
0
8
15
8
15
0
% K
% Leu:
15
15
8
29
0
36
8
0
0
15
8
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% M
% Asn:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
8
0
0
0
8
0
8
8
0
0
8
8
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
22
0
36
8
8
0
0
0
% Q
% Arg:
8
0
8
0
0
0
0
8
0
0
0
0
8
22
0
% R
% Ser:
0
8
0
0
8
0
0
8
0
8
0
8
8
8
8
% S
% Thr:
8
0
0
8
0
0
0
0
0
0
8
8
8
0
8
% T
% Val:
0
0
0
0
0
8
0
0
0
8
0
8
0
0
8
% V
% Trp:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
29
8
0
8
0
22
0
29
0
0
0
8
0
15
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _