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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICK All Species: 19.7
Human Site: S335 Identified Species: 39.39
UniProt: Q9UPZ9 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPZ9 NP_055735.1 632 71427 S335 K P H T R I S S R Q H Q A S Q
Chimpanzee Pan troglodytes XP_001154965 633 71532 S336 K P Q T R I S S R Q H Q A S Q
Rhesus Macaque Macaca mulatta XP_001100720 616 68399 S319 K P H T R I S S R Q H Q A S Q
Dog Lupus familis XP_538964 685 76968 S388 K P H P R I S S R Q H Q G S Q
Cat Felis silvestris
Mouse Mus musculus Q9JKV2 629 70573 S332 K A Y T L I S S R P S Q A S Q
Rat Rattus norvegicus Q62726 629 70550 S332 K A H T L I S S R P N Q A S Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514373 624 70740 D329 Q H P L N A L D K N Q L Q A Q
Chicken Gallus gallus
Frog Xenopus laevis P23437 297 33852
Zebra Danio Brachydanio rerio NP_956240 633 71283 N335 Q T K G Q S R N S H Q P L Q Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392924 569 65790 A275 N P I K R P T A Q Q S L R Y P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001200813 576 64528 K282 A A Q C L K Y K Y F Q V G Q N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43294 443 50877 I148 V T N N I L K I A D F G L A R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 86.8 86.1 N.A. 86.3 85.5 N.A. 56.6 N.A. 23.1 47 N.A. N.A. 45.8 N.A. 48.5
Protein Similarity: 100 99.5 90 89.4 N.A. 92 91.6 N.A. 68.8 N.A. 32.1 60.5 N.A. N.A. 61.3 N.A. 62.1
P-Site Identity: 100 93.3 100 86.6 N.A. 66.6 73.3 N.A. 6.6 N.A. 0 6.6 N.A. N.A. 20 N.A. 0
P-Site Similarity: 100 93.3 100 86.6 N.A. 73.3 80 N.A. 26.6 N.A. 0 26.6 N.A. N.A. 40 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. 34.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 25 0 0 0 9 0 9 9 0 0 0 42 17 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 9 0 9 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 9 9 0 0 0 0 % F
% Gly: 0 0 0 9 0 0 0 0 0 0 0 9 17 0 0 % G
% His: 0 9 34 0 0 0 0 0 0 9 34 0 0 0 0 % H
% Ile: 0 0 9 0 9 50 0 9 0 0 0 0 0 0 0 % I
% Lys: 50 0 9 9 0 9 9 9 9 0 0 0 0 0 0 % K
% Leu: 0 0 0 9 25 9 9 0 0 0 0 17 17 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 9 9 9 0 0 9 0 9 9 0 0 0 9 % N
% Pro: 0 42 9 9 0 9 0 0 0 17 0 9 0 0 9 % P
% Gln: 17 0 17 0 9 0 0 0 9 42 25 50 9 17 67 % Q
% Arg: 0 0 0 0 42 0 9 0 50 0 0 0 9 0 9 % R
% Ser: 0 0 0 0 0 9 50 50 9 0 17 0 0 50 0 % S
% Thr: 0 17 0 42 0 0 9 0 0 0 0 0 0 0 0 % T
% Val: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 9 0 9 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _