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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICK All Species: 19.09
Human Site: S466 Identified Species: 38.18
UniProt: Q9UPZ9 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPZ9 NP_055735.1 632 71427 S466 E P V G T G N S A P T Q T S Y
Chimpanzee Pan troglodytes XP_001154965 633 71532 S467 E P V G T G N S A P T Q T S Y
Rhesus Macaque Macaca mulatta XP_001100720 616 68399 S450 E P V G T G N S A P T Q M S Y
Dog Lupus familis XP_538964 685 76968 S519 E P V G T G N S A P T Q T S Y
Cat Felis silvestris
Mouse Mus musculus Q9JKV2 629 70573 T463 E S V G T G T T V S T Q A S S
Rat Rattus norvegicus Q62726 629 70550 S463 E P V G T G T S V S T Q A S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514373 624 70740 G460 E N K S L P A G A F L K N D T
Chicken Gallus gallus
Frog Xenopus laevis P23437 297 33852 L134 D L K P Q N L L I N S D G A I
Zebra Danio Brachydanio rerio NP_956240 633 71283 G466 R Q S R Y M P G L I S K N T Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392924 569 65790 L406 A N W N V N Y L P E N P R N W
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001200813 576 64528 K413 G T S A K T K K I G G M K G K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43294 443 50877 R279 C S W D P L K R P T A D E A L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 86.8 86.1 N.A. 86.3 85.5 N.A. 56.6 N.A. 23.1 47 N.A. N.A. 45.8 N.A. 48.5
Protein Similarity: 100 99.5 90 89.4 N.A. 92 91.6 N.A. 68.8 N.A. 32.1 60.5 N.A. N.A. 61.3 N.A. 62.1
P-Site Identity: 100 100 93.3 100 N.A. 53.3 66.6 N.A. 13.3 N.A. 0 0 N.A. N.A. 0 N.A. 0
P-Site Similarity: 100 100 93.3 100 N.A. 60 66.6 N.A. 20 N.A. 20 20 N.A. N.A. 13.3 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. 34.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 9 0 0 9 0 42 0 9 0 17 17 0 % A
% Cys: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 9 0 0 0 0 0 0 0 17 0 9 0 % D
% Glu: 59 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % F
% Gly: 9 0 0 50 0 50 0 17 0 9 9 0 9 9 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 17 9 0 0 0 0 9 % I
% Lys: 0 0 17 0 9 0 17 9 0 0 0 17 9 0 9 % K
% Leu: 0 9 0 0 9 9 9 17 9 0 9 0 0 0 9 % L
% Met: 0 0 0 0 0 9 0 0 0 0 0 9 9 0 0 % M
% Asn: 0 17 0 9 0 17 34 0 0 9 9 0 17 9 0 % N
% Pro: 0 42 0 9 9 9 9 0 17 34 0 9 0 0 0 % P
% Gln: 0 9 0 0 9 0 0 0 0 0 0 50 0 0 9 % Q
% Arg: 9 0 0 9 0 0 0 9 0 0 0 0 9 0 0 % R
% Ser: 0 17 17 9 0 0 0 42 0 17 17 0 0 50 17 % S
% Thr: 0 9 0 0 50 9 17 9 0 9 50 0 25 9 9 % T
% Val: 0 0 50 0 9 0 0 0 17 0 0 0 0 0 0 % V
% Trp: 0 0 17 0 0 0 0 0 0 0 0 0 0 0 9 % W
% Tyr: 0 0 0 0 9 0 9 0 0 0 0 0 0 0 34 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _