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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHDH All Species: 4.55
Human Site: S309 Identified Species: 10
UniProt: Q9UQ10 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQ10 NP_055290.1 334 36382 S309 E S P V I P L S E S E L L A D
Chimpanzee Pan troglodytes XP_512808 334 36395 S309 E S P V I P L S E S E L L A D
Rhesus Macaque Macaca mulatta XP_001112315 408 44331 V309 E S P V I P L V E S E L L A D
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q9DBB8 333 36282 A308 E S P V V P L A E S E L L A E
Rat Rattus norvegicus XP_002725668 333 36244 A308 E S P V V P L A E S E L L A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6DKE0 330 36328 L308 K E S P I M S L A D S E M I A
Zebra Danio Brachydanio rerio Q642M9 334 36548 A309 E S S R M S H A D S A L L A D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608675 335 37267 A310 E N K N V T Y A D S L I F A E
Honey Bee Apis mellifera XP_623497 331 36880 N308 E S P K V P H N V S L L I A Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786234 350 38766 K318 E H A L M S W K E T E L I A T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SZ83 362 39544 N324 L V G E I K N N G A K P D G Y
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.7 77.2 N.A. N.A. 78.7 77.2 N.A. N.A. N.A. 51.7 50.5 N.A. 43.2 41.9 N.A. 39.1
Protein Similarity: 100 97.3 79.1 N.A. N.A. 86.5 86.8 N.A. N.A. N.A. 71.8 68.5 N.A. 60 58.3 N.A. 57.4
P-Site Identity: 100 100 93.3 N.A. N.A. 80 80 N.A. N.A. N.A. 6.6 46.6 N.A. 20 46.6 N.A. 33.3
P-Site Similarity: 100 100 93.3 N.A. N.A. 100 100 N.A. N.A. N.A. 20 66.6 N.A. 60 66.6 N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. 23.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 40.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 37 10 10 10 0 0 82 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 19 10 0 0 10 0 37 % D
% Glu: 82 10 0 10 0 0 0 0 55 0 55 10 0 0 28 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 0 10 0 0 0 0 0 10 0 0 0 0 10 0 % G
% His: 0 10 0 0 0 0 19 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 46 0 0 0 0 0 0 10 19 10 0 % I
% Lys: 10 0 10 10 0 10 0 10 0 0 10 0 0 0 0 % K
% Leu: 10 0 0 10 0 0 46 10 0 0 19 73 55 0 0 % L
% Met: 0 0 0 0 19 10 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 10 0 10 0 0 10 19 0 0 0 0 0 0 0 % N
% Pro: 0 0 55 10 0 55 0 0 0 0 0 10 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % Q
% Arg: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 64 19 0 0 19 10 19 0 73 10 0 0 0 0 % S
% Thr: 0 0 0 0 0 10 0 0 0 10 0 0 0 0 10 % T
% Val: 0 10 0 46 37 0 0 10 10 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _