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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXO1
All Species:
8.18
Human Site:
S446
Identified Species:
15
UniProt:
Q9UQ84
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UQ84
NP_003677.3
846
94103
S446
T
K
K
T
K
K
N
S
S
E
G
N
K
S
L
Chimpanzee
Pan troglodytes
XP_001160902
846
94086
S446
M
K
K
T
K
K
N
S
S
E
G
N
K
S
L
Rhesus Macaque
Macaca mulatta
XP_001093427
846
94132
S446
T
K
K
T
K
R
N
S
Y
E
G
N
I
S
L
Dog
Lupus familis
XP_547491
836
92524
N446
T
K
K
T
K
K
N
N
C
E
G
P
K
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ11
837
92003
V436
L
L
S
Q
Y
S
S
V
S
K
K
I
K
E
N
Rat
Rattus norvegicus
NP_001100668
836
91871
C445
K
K
I
R
E
N
S
C
G
N
G
T
S
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514118
820
89598
D446
N
T
K
K
A
K
E
D
P
G
P
E
G
R
G
Chicken
Gallus gallus
XP_419550
807
90135
K406
I
I
S
I
K
G
L
K
L
P
G
K
E
L
F
Frog
Xenopus laevis
Q9W6K2
734
82213
D369
N
R
K
T
A
H
T
D
S
I
W
Y
T
K
S
Zebra Danio
Brachydanio rerio
Q803U7
806
88576
D430
E
D
T
S
L
S
V
D
D
L
L
E
Q
Y
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24558
732
83163
Q367
S
K
H
K
S
I
W
Q
T
N
F
Q
S
E
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L6Z7
735
82230
L370
D
L
P
V
Q
K
N
L
L
T
K
Y
F
C
F
Baker's Yeast
Sacchar. cerevisiae
P39875
702
80144
I337
I
V
H
F
D
D
D
I
D
H
H
L
H
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
95.5
82
N.A.
72.6
75.5
N.A.
60.8
58.1
49.2
48.1
N.A.
30.1
N.A.
N.A.
N.A.
Protein Similarity:
100
99.1
97
88
N.A.
81.8
82.8
N.A.
72.6
71.5
62.1
62.4
N.A.
48.3
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
80
80
N.A.
13.3
13.3
N.A.
13.3
13.3
20
0
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
86.6
86.6
N.A.
26.6
26.6
N.A.
13.3
20
26.6
13.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.3
25.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.1
44.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
16
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
8
0
0
0
0
8
0
% C
% Asp:
8
8
0
0
8
8
8
24
16
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
8
0
8
0
0
31
0
16
8
16
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
8
0
8
0
16
% F
% Gly:
0
0
0
0
0
8
0
0
8
8
47
0
8
0
8
% G
% His:
0
0
16
0
0
8
0
0
0
8
8
0
8
0
0
% H
% Ile:
16
8
8
8
0
8
0
8
0
8
0
8
8
0
0
% I
% Lys:
8
47
47
16
39
39
0
8
0
8
16
8
31
8
8
% K
% Leu:
8
16
0
0
8
0
8
8
16
8
8
8
0
16
31
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
0
0
0
0
8
39
8
0
16
0
24
0
0
24
% N
% Pro:
0
0
8
0
0
0
0
0
8
8
8
8
0
8
0
% P
% Gln:
0
0
0
8
8
0
0
8
0
0
0
8
8
0
0
% Q
% Arg:
0
8
0
8
0
8
0
0
0
0
0
0
0
8
0
% R
% Ser:
8
0
16
8
8
16
16
24
31
0
0
0
16
31
8
% S
% Thr:
24
8
8
39
0
0
8
0
8
8
0
8
8
0
8
% T
% Val:
0
8
0
8
0
0
8
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
8
0
0
16
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _