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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EXO1 All Species: 12.12
Human Site: S649 Identified Species: 22.22
UniProt: Q9UQ84 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQ84 NP_003677.3 846 94103 S649 S L P E N N M S D V S Q L K S
Chimpanzee Pan troglodytes XP_001160902 846 94086 S649 S L P E N N M S D V S Q L K S
Rhesus Macaque Macaca mulatta XP_001093427 846 94132 S650 S L P E I S M S D V S Q L K S
Dog Lupus familis XP_547491 836 92524 E651 R S D E S G D E A P P S R L A
Cat Felis silvestris
Mouse Mus musculus Q9QZ11 837 92003 V640 C L P E A S A V V T D R C D S
Rat Rattus norvegicus NP_001100668 836 91871 D653 S K S G T L G D K S Q S L H E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514118 820 89598 S652 P A A A E R L S P G S R N S S
Chicken Gallus gallus XP_419550 807 90135 V607 Q A D D S N G V Q A E S G A V
Frog Xenopus laevis Q9W6K2 734 82213 L569 C F T W S G S L D S E S S P T
Zebra Danio Brachydanio rerio Q803U7 806 88576 S632 A G P G L S L S S S P V E G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24558 732 83163 N567 C K D I P G K N P I R Q R C S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L6Z7 735 82230 N570 T I N T H K I N H Q I N E E E
Baker's Yeast Sacchar. cerevisiae P39875 702 80144 D537 G N E I Y N T D D D G D G D T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 95.5 82 N.A. 72.6 75.5 N.A. 60.8 58.1 49.2 48.1 N.A. 30.1 N.A. N.A. N.A.
Protein Similarity: 100 99.1 97 88 N.A. 81.8 82.8 N.A. 72.6 71.5 62.1 62.4 N.A. 48.3 N.A. N.A. N.A.
P-Site Identity: 100 100 86.6 6.6 N.A. 26.6 13.3 N.A. 20 6.6 6.6 20 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 20 N.A. 40 13.3 N.A. 33.3 20 20 40 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.3 25.4 N.A.
Protein Similarity: N.A. N.A. N.A. 45.1 44.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 16 8 8 8 0 8 0 8 8 0 0 0 8 8 % A
% Cys: 24 0 0 0 0 0 0 0 0 0 0 0 8 8 0 % C
% Asp: 0 0 24 8 0 0 8 16 39 8 8 8 0 16 0 % D
% Glu: 0 0 8 39 8 0 0 8 0 0 16 0 16 8 16 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 8 0 16 0 24 16 0 0 8 8 0 16 8 0 % G
% His: 0 0 0 0 8 0 0 0 8 0 0 0 0 8 0 % H
% Ile: 0 8 0 16 8 0 8 0 0 8 8 0 0 0 0 % I
% Lys: 0 16 0 0 0 8 8 0 8 0 0 0 0 24 0 % K
% Leu: 0 31 0 0 8 8 16 8 0 0 0 0 31 8 0 % L
% Met: 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 16 31 0 16 0 0 0 8 8 0 0 % N
% Pro: 8 0 39 0 8 0 0 0 16 8 16 0 0 8 0 % P
% Gln: 8 0 0 0 0 0 0 0 8 8 8 31 0 0 0 % Q
% Arg: 8 0 0 0 0 8 0 0 0 0 8 16 16 0 0 % R
% Ser: 31 8 8 0 24 24 8 39 8 24 31 31 8 8 54 % S
% Thr: 8 0 8 8 8 0 8 0 0 8 0 0 0 0 16 % T
% Val: 0 0 0 0 0 0 0 16 8 24 0 8 0 0 8 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _