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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EXO1 All Species: 10.91
Human Site: S746 Identified Species: 20
UniProt: Q9UQ84 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQ84 NP_003677.3 846 94103 S746 P G L Y K S S S A D S L S T T
Chimpanzee Pan troglodytes XP_001160902 846 94086 S746 P G L Y K S S S A D S L S T T
Rhesus Macaque Macaca mulatta XP_001093427 846 94132 A747 G L Y K S S S A D S L S A T K
Dog Lupus familis XP_547491 836 92524 P748 T K I K P L V P A R A S G L S
Cat Felis silvestris
Mouse Mus musculus Q9QZ11 837 92003 S737 P G L C R S S S M D S F S T T
Rat Rattus norvegicus NP_001100668 836 91871 P750 T K I K P L V P A R V S G L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514118 820 89598 G749 R P A A G P K G F G H D V E N
Chicken Gallus gallus XP_419550 807 90135 S704 V P G L R K S S S V G S H I V
Frog Xenopus laevis Q9W6K2 734 82213 G666 S F F P E P K G S A P K S K V
Zebra Danio Brachydanio rerio Q803U7 806 88576 A729 G G K I E T S A P A R A S G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24558 732 83163 S664 L S D D S C S S D Q R A S S T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L6Z7 735 82230 I667 H I G H Y S E I A E K S V E R
Baker's Yeast Sacchar. cerevisiae P39875 702 80144 P634 K N Q I T Q R P S L R K S L I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 95.5 82 N.A. 72.6 75.5 N.A. 60.8 58.1 49.2 48.1 N.A. 30.1 N.A. N.A. N.A.
Protein Similarity: 100 99.1 97 88 N.A. 81.8 82.8 N.A. 72.6 71.5 62.1 62.4 N.A. 48.3 N.A. N.A. N.A.
P-Site Identity: 100 100 20 6.6 N.A. 73.3 6.6 N.A. 0 13.3 6.6 20 N.A. 26.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 33.3 26.6 N.A. 80 20 N.A. 0 26.6 20 40 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.3 25.4 N.A.
Protein Similarity: N.A. N.A. N.A. 45.1 44.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 0 0 0 16 39 16 8 16 8 0 0 % A
% Cys: 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 8 0 0 0 0 16 24 0 8 0 0 0 % D
% Glu: 0 0 0 0 16 0 8 0 0 8 0 0 0 16 0 % E
% Phe: 0 8 8 0 0 0 0 0 8 0 0 8 0 0 0 % F
% Gly: 16 31 16 0 8 0 0 16 0 8 8 0 16 8 0 % G
% His: 8 0 0 8 0 0 0 0 0 0 8 0 8 0 0 % H
% Ile: 0 8 16 16 0 0 0 8 0 0 0 0 0 8 8 % I
% Lys: 8 16 8 24 16 8 16 0 0 0 8 16 0 8 8 % K
% Leu: 8 8 24 8 0 16 0 0 0 8 8 16 0 24 8 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 24 16 0 8 16 16 0 24 8 0 8 0 0 0 0 % P
% Gln: 0 0 8 0 0 8 0 0 0 8 0 0 0 0 0 % Q
% Arg: 8 0 0 0 16 0 8 0 0 16 24 0 0 0 8 % R
% Ser: 8 8 0 0 16 39 54 39 24 8 24 39 54 8 16 % S
% Thr: 16 0 0 0 8 8 0 0 0 0 0 0 0 31 31 % T
% Val: 8 0 0 0 0 0 16 0 0 8 8 0 16 0 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 16 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _