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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPG7 All Species: 6.67
Human Site: S46 Identified Species: 11.28
UniProt: Q9UQ90 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.31
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQ90 NP_003110.1 795 88235 S46 R G R P Y M A S R P P G D L A
Chimpanzee Pan troglodytes XP_001140249 795 88440 S46 R G R P Y M A S R P P G D L A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546777 917 101667 H170 R R C L H F V H R P P T R L V
Cat Felis silvestris
Mouse Mus musculus Q3ULF4 781 85978 R46 A R R P Y A A R G T P V G P A
Rat Rattus norvegicus Q7TT47 744 82104 R46 G R R P Y V V R G T P I G L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511408 749 83486 K24 N K Q R R A T K L L S R T L S
Chicken Gallus gallus NP_001012545 768 86064 R28 A W A R P R P R G P Q G F L S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923118 788 88169 N37 S R K L I K S N V T P L V I P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_570017 819 90064 L41 R E L S L L Q L S R R Q V M Q
Honey Bee Apis mellifera XP_393770 707 80119 S26 K E L S E I Q S L L S K N K F
Nematode Worm Caenorhab. elegans NP_500191 747 82795 A37 V L P H I L S A R R F P Q R R
Sea Urchin Strong. purpuratus XP_001202193 915 101037 T106 K C Q Y L E L T G V G C G S N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8VZI8 813 89536 A44 A P Q N L E A A V N Q V D G G
Baker's Yeast Sacchar. cerevisiae P40341 825 93258 N40 H T Q Y R L L N R L Q E N K S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.4 N.A. 78.4 N.A. 86.9 82.3 N.A. 80.8 70.5 N.A. 73.9 N.A. 47.8 43.9 43.9 48.2
Protein Similarity: 100 97.3 N.A. 81.7 N.A. 91.4 87.1 N.A. 88.1 83.1 N.A. 84.5 N.A. 64.3 60.3 62.5 62
P-Site Identity: 100 100 N.A. 33.3 N.A. 40 40 N.A. 6.6 20 N.A. 6.6 N.A. 6.6 6.6 6.6 0
P-Site Similarity: 100 100 N.A. 40 N.A. 40 46.6 N.A. 20 26.6 N.A. 33.3 N.A. 20 26.6 26.6 20
Percent
Protein Identity: N.A. N.A. N.A. 37.7 39.1 N.A.
Protein Similarity: N.A. N.A. N.A. 57.3 56.4 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 0 8 0 0 15 29 15 0 0 0 0 0 0 29 % A
% Cys: 0 8 8 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 22 0 0 % D
% Glu: 0 15 0 0 8 15 0 0 0 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 8 0 8 0 8 % F
% Gly: 8 15 0 0 0 0 0 0 29 0 8 22 22 8 8 % G
% His: 8 0 0 8 8 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 15 8 0 0 0 0 0 8 0 8 0 % I
% Lys: 15 8 8 0 0 8 0 8 0 0 0 8 0 15 0 % K
% Leu: 0 8 15 15 22 22 15 8 15 22 0 8 0 43 0 % L
% Met: 0 0 0 0 0 15 0 0 0 0 0 0 0 8 0 % M
% Asn: 8 0 0 8 0 0 0 15 0 8 0 0 15 0 8 % N
% Pro: 0 8 8 29 8 0 8 0 0 29 43 8 0 8 8 % P
% Gln: 0 0 29 0 0 0 15 0 0 0 22 8 8 0 8 % Q
% Arg: 29 29 29 15 15 8 0 22 36 15 8 8 8 8 8 % R
% Ser: 8 0 0 15 0 0 15 22 8 0 15 0 0 8 22 % S
% Thr: 0 8 0 0 0 0 8 8 0 22 0 8 8 0 0 % T
% Val: 8 0 0 0 0 8 15 0 15 8 0 15 15 0 8 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 15 29 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _