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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPG7 All Species: 8.79
Human Site: S501 Identified Species: 14.87
UniProt: Q9UQ90 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQ90 NP_003110.1 795 88235 S501 K S L K L T Q S S T F Y S Q R
Chimpanzee Pan troglodytes XP_001140249 795 88440 S501 K S L K L T Q S S T F Y S Q R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546777 917 101667 A625 K S L K L T Q A S S F Y S Q R
Cat Felis silvestris
Mouse Mus musculus Q3ULF4 781 85978 P501 K G L K L T Q P S S F Y S Q R
Rat Rattus norvegicus Q7TT47 744 82104 P468 L D N A L M R P G R L D R H V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511408 749 83486 T463 K S L K L T Q T G T F Y S Q R
Chicken Gallus gallus NP_001012545 768 86064 D474 K G L K L I Q D A S F Y S Q H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923118 788 88169 P492 K I L K L T Q P A D F Y S L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_570017 819 90064 P535 S S V K L E S P P T T F S Q R
Honey Bee Apis mellifera XP_393770 707 80119 K439 Q S L L L K D K P I K Y S K Y
Nematode Worm Caenorhab. elegans NP_500191 747 82795 A482 R K I K L D H A P Q E Y S Q R
Sea Urchin Strong. purpuratus XP_001202193 915 101037 K624 K K L V L K G K P A D Y S T R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8VZI8 813 89536 E519 K K I K L D H E P S Y Y S Q R
Baker's Yeast Sacchar. cerevisiae P40341 825 93258 E540 H H L K L A G E I F D L K N R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.4 N.A. 78.4 N.A. 86.9 82.3 N.A. 80.8 70.5 N.A. 73.9 N.A. 47.8 43.9 43.9 48.2
Protein Similarity: 100 97.3 N.A. 81.7 N.A. 91.4 87.1 N.A. 88.1 83.1 N.A. 84.5 N.A. 64.3 60.3 62.5 62
P-Site Identity: 100 100 N.A. 86.6 N.A. 80 6.6 N.A. 86.6 60 N.A. 66.6 N.A. 46.6 33.3 40 40
P-Site Similarity: 100 100 N.A. 100 N.A. 86.6 13.3 N.A. 93.3 73.3 N.A. 73.3 N.A. 60 46.6 60 40
Percent
Protein Identity: N.A. N.A. N.A. 37.7 39.1 N.A.
Protein Similarity: N.A. N.A. N.A. 57.3 56.4 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 8 0 15 15 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 15 8 8 0 8 15 8 0 0 0 % D
% Glu: 0 0 0 0 0 8 0 15 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 50 8 0 0 0 % F
% Gly: 0 15 0 0 0 0 15 0 15 0 0 0 0 0 0 % G
% His: 8 8 0 0 0 0 15 0 0 0 0 0 0 8 8 % H
% Ile: 0 8 15 0 0 8 0 0 8 8 0 0 0 0 0 % I
% Lys: 65 22 0 79 0 15 0 15 0 0 8 0 8 8 0 % K
% Leu: 8 0 72 8 100 0 0 0 0 0 8 8 0 8 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 0 0 0 0 0 0 29 36 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 0 0 50 0 0 8 0 0 0 65 0 % Q
% Arg: 8 0 0 0 0 0 8 0 0 8 0 0 8 0 79 % R
% Ser: 8 43 0 0 0 0 8 15 29 29 0 0 86 0 0 % S
% Thr: 0 0 0 0 0 43 0 8 0 29 8 0 0 8 0 % T
% Val: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 79 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _