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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC3 All Species: 35.76
Human Site: Y560 Identified Species: 56.19
UniProt: Q9UQE7 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQE7 NP_005436.1 1217 141542 Y560 T A G N R L F Y H I V D S D E
Chimpanzee Pan troglodytes XP_508031 1374 158072 Y717 T A G N R L F Y H I V D S D E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_851818 1228 142683 Y560 T A G N R L F Y H I V D S D E
Cat Felis silvestris
Mouse Mus musculus Q9CW03 1217 141537 Y560 T A G N R L F Y H I V D S D E
Rat Rattus norvegicus P97690 1191 138430 Y560 T A G N R L F Y H I V D S D E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512851 1238 143475 Y581 T A G N R L F Y H I V D S D E
Chicken Gallus gallus Q90988 1189 134923 N551 V A G G K L Y N I V V D T E A
Frog Xenopus laevis O93309 1209 140704 Y560 T A G N R L F Y H I V E S D E
Zebra Danio Brachydanio rerio NP_999854 1216 141517 Y560 T A G T R L F Y H I V E T D E
Tiger Blowfish Takifugu rubipres NP_001027798 1217 141541 Y560 T A G T R L F Y H I V E T D E
Fruit Fly Dros. melanogaster NP_523374 1200 140018 H561 T A A N R L F H H I V E S E Y
Honey Bee Apis mellifera XP_393700 1202 139436 H560 T A G N R L F H H I V E T D K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001202053 792 92535 R219 L E D L A N K R E N S G E M T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SN90 1171 132296 N549 T A G G K L F N V I V D T E D
Baker's Yeast Sacchar. cerevisiae P47037 1230 141318 H564 I G G N S L F H I V V D T E E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.5 N.A. 99 N.A. 99.9 97.2 N.A. 97.5 23.3 95.8 95.1 94.9 53.4 55.4 N.A. 40.1
Protein Similarity: 100 88.5 N.A. 99 N.A. 100 97.4 N.A. 98 46.5 97.6 97.5 97.3 73.2 72.9 N.A. 53.9
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 33.3 93.3 80 80 66.6 73.3 N.A. 0
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 66.6 100 93.3 93.3 86.6 100 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. 24 33.1 N.A.
Protein Similarity: N.A. N.A. N.A. 47 57.8 N.A.
P-Site Identity: N.A. N.A. N.A. 53.3 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 87 7 0 7 0 0 0 0 0 0 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 0 0 0 0 0 0 0 60 0 67 7 % D
% Glu: 0 7 0 0 0 0 0 0 7 0 0 34 7 27 67 % E
% Phe: 0 0 0 0 0 0 87 0 0 0 0 0 0 0 0 % F
% Gly: 0 7 87 14 0 0 0 0 0 0 0 7 0 0 0 % G
% His: 0 0 0 0 0 0 0 20 74 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 14 80 0 0 0 0 0 % I
% Lys: 0 0 0 0 14 0 7 0 0 0 0 0 0 0 7 % K
% Leu: 7 0 0 7 0 94 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 0 67 0 7 0 14 0 7 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 74 0 0 7 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 7 0 0 0 0 0 7 0 54 0 0 % S
% Thr: 80 0 0 14 0 0 0 0 0 0 0 0 40 0 7 % T
% Val: 7 0 0 0 0 0 0 0 7 14 94 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 60 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _