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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ENTPD4
All Species:
8.79
Human Site:
S596
Identified Species:
17.58
UniProt:
Q9Y227
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y227
NP_001122402.1
616
70255
S596
H
R
R
T
P
R
S
S
S
A
A
A
L
W
M
Chimpanzee
Pan troglodytes
XP_519659
710
80224
S690
H
R
R
T
P
R
S
S
S
A
A
A
L
W
M
Rhesus Macaque
Macaca mulatta
XP_001108472
728
82237
G708
H
R
R
T
L
R
N
G
S
A
A
A
L
W
M
Dog
Lupus familis
XP_543243
608
69462
A588
H
R
R
T
L
R
S
A
S
T
A
T
L
W
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBT4
613
69727
G596
H
R
R
A
P
R
T
G
S
L
W
M
E
E
G
Rat
Rattus norvegicus
P97687
511
57389
T495
V
L
V
A
M
V
I
T
G
L
F
I
F
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507040
633
71884
G612
H
R
R
M
L
R
N
G
S
S
A
S
L
W
M
Chicken
Gallus gallus
P79784
495
54515
A479
F
V
I
T
T
L
T
A
L
L
T
A
V
Y
L
Frog
Xenopus laevis
NP_001088548
616
70594
T596
H
R
R
M
Q
R
N
T
S
S
S
A
L
W
V
Zebra Danio
Brachydanio rerio
NP_001002419
611
69763
R589
H
N
R
S
M
L
H
R
S
A
S
A
S
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21815
552
62492
K536
S
R
S
Q
Y
S
Y
K
M
L
K
E
N
R
T
Sea Urchin
Strong. purpuratus
XP_785341
537
60729
V520
S
L
I
H
D
K
E
V
Q
W
T
L
G
A
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
82.2
93.5
N.A.
93
26.4
N.A.
86.5
24.5
77.1
70.6
N.A.
N.A.
N.A.
30.6
48.5
Protein Similarity:
100
85.4
82.8
96.4
N.A.
97.5
47.4
N.A.
92
42.6
88.4
84.2
N.A.
N.A.
N.A.
48.8
63.3
P-Site Identity:
100
100
80
66.6
N.A.
40
0
N.A.
60
13.3
53.3
33.3
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
86.6
80
N.A.
46.6
6.6
N.A.
80
46.6
86.6
46.6
N.A.
N.A.
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
0
0
0
17
0
34
42
50
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
9
0
0
0
0
9
9
9
0
% E
% Phe:
9
0
0
0
0
0
0
0
0
0
9
0
9
0
0
% F
% Gly:
0
0
0
0
0
0
0
25
9
0
0
0
9
0
9
% G
% His:
67
0
0
9
0
0
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
17
0
0
0
9
0
0
0
0
9
0
0
9
% I
% Lys:
0
0
0
0
0
9
0
9
0
0
9
0
0
0
9
% K
% Leu:
0
17
0
0
25
17
0
0
9
34
0
9
50
0
17
% L
% Met:
0
0
0
17
17
0
0
0
9
0
0
9
0
0
34
% M
% Asn:
0
9
0
0
0
0
25
0
0
0
0
0
9
0
0
% N
% Pro:
0
0
0
0
25
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
9
9
0
0
0
9
0
0
0
0
0
9
% Q
% Arg:
0
67
67
0
0
59
0
9
0
0
0
0
0
9
0
% R
% Ser:
17
0
9
9
0
9
25
17
67
17
17
9
9
9
0
% S
% Thr:
0
0
0
42
9
0
17
17
0
9
17
9
0
0
9
% T
% Val:
9
9
9
0
0
9
0
9
0
0
0
0
9
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
9
0
0
50
0
% W
% Tyr:
0
0
0
0
9
0
9
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _