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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE10A
All Species:
23.33
Human Site:
S766
Identified Species:
42.78
UniProt:
Q9Y233
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y233
NP_001124162.1
779
88412
S766
E
E
T
A
T
W
I
S
S
P
S
V
A
Q
K
Chimpanzee
Pan troglodytes
XP_518849
940
103297
S927
E
E
T
A
T
W
I
S
S
P
S
V
A
Q
K
Rhesus Macaque
Macaca mulatta
XP_001105004
806
91361
S793
E
E
T
A
T
W
I
S
S
P
S
V
A
Q
K
Dog
Lupus familis
XP_541190
794
89954
S776
E
E
S
A
V
W
I
S
S
P
P
G
A
H
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CA95
790
89389
S770
E
E
T
A
M
W
I
S
G
P
G
P
A
P
S
Rat
Rattus norvegicus
Q9QYJ6
794
90143
S776
E
E
T
A
M
W
I
S
G
P
A
T
S
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506107
745
84517
Y727
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
F
Chicken
Gallus gallus
P52731
862
99990
I826
Y
E
E
K
M
K
V
I
E
E
Q
K
K
K
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957396
843
95237
S775
E
D
V
S
A
W
S
S
T
E
E
A
E
V
S
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
S873
R
Q
H
D
H
G
A
S
V
P
A
S
P
C
S
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
D1114
V
K
T
K
T
S
Q
D
Q
E
P
E
E
E
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P91119
710
81117
A697
L
H
A
W
D
L
Y
A
L
L
R
L
N
R
A
Sea Urchin
Strong. purpuratus
XP_789134
701
80204
S689
V
K
E
G
K
A
A
S
M
W
N
V
A
T
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.4
95
94.3
N.A.
93.1
92.9
N.A.
89.2
23.2
N.A.
77.4
27.8
20
N.A.
35.1
38.9
Protein Similarity:
100
82.6
96
95.8
N.A.
95.9
95.7
N.A.
92
41.5
N.A.
84.8
49
32.6
N.A.
54.6
58.7
P-Site Identity:
100
100
100
60
N.A.
60
53.3
N.A.
6.6
6.6
N.A.
20
13.3
13.3
N.A.
0
20
P-Site Similarity:
100
100
100
66.6
N.A.
60
73.3
N.A.
13.3
26.6
N.A.
40
26.6
33.3
N.A.
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
54
8
8
16
8
0
0
16
8
47
0
8
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% C
% Asp:
0
8
0
8
8
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
54
54
16
0
0
0
0
0
8
24
8
8
16
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
8
0
8
0
0
16
0
8
8
0
0
8
% G
% His:
0
8
8
0
8
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
8
0
47
8
0
0
0
0
0
8
0
% I
% Lys:
0
16
0
16
8
8
0
0
0
0
0
8
8
16
24
% K
% Leu:
8
0
0
0
0
8
0
0
8
8
8
8
0
0
0
% L
% Met:
0
0
0
0
24
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
54
16
8
8
8
0
% P
% Gln:
0
8
0
0
0
0
8
0
8
0
8
0
8
24
8
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% R
% Ser:
0
0
8
8
0
8
8
70
31
0
24
8
8
0
39
% S
% Thr:
0
0
47
0
31
0
0
0
16
8
0
16
0
8
0
% T
% Val:
16
0
16
0
8
0
8
0
8
0
0
31
0
8
0
% V
% Trp:
0
0
0
8
0
54
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _