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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLH All Species: 15.45
Human Site: S369 Identified Species: 28.33
UniProt: Q9Y253 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y253 NP_006493.1 713 78413 S369 V A T Q L V V S I R V Q G D K
Chimpanzee Pan troglodytes XP_518497 713 78354 S369 V A T Q L V V S I R V Q G D K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532150 712 78332 S369 V A T Q L A V S I R V Q G D K
Cat Felis silvestris
Mouse Mus musculus Q9JJN0 694 76148 R350 L A L E L E E R L T K D R N D
Rat Rattus norvegicus NP_001101674 689 75727 E346 W L L Q L A L E L E E R L T K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516192 729 78058 S369 V A T H L S V S A R I Q G D K
Chicken Gallus gallus NP_001001304 673 73621 A330 F P G K T A L A T Q K E V Q H
Frog Xenopus laevis NP_001087074 684 75120 Q337 L S T R E Q V Q Y W L L Q L S
Zebra Danio Brachydanio rerio NP_001035337 743 82024 G368 V A R Q L T V G V R Q A G G Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649371 885 99008 Q384 R A K H M V V Q Y V Q D I D G
Honey Bee Apis mellifera XP_001122310 429 48500 G86 V S V P C L R G K A D I S R Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797437 822 90146 S359 T A K H L T V S V G Q A G K P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568638 672 73967 S328 P G P R A L K S L S T V Q H W
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.2 N.A. 79.6 77.6 N.A. 64.4 51.8 53.1 46.7 N.A. 31.2 27.9 N.A. 38.5
Protein Similarity: 100 99.7 N.A. 90.8 N.A. 85.9 85.1 N.A. 73.6 68 67.7 61.5 N.A. 48.4 40.3 N.A. 55.6
P-Site Identity: 100 100 N.A. 93.3 N.A. 13.3 20 N.A. 73.3 0 13.3 46.6 N.A. 26.6 6.6 N.A. 33.3
P-Site Similarity: 100 100 N.A. 93.3 N.A. 40 40 N.A. 80 33.3 40 60 N.A. 33.3 20 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. 31.7 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 62 0 0 8 24 0 8 8 8 0 16 0 0 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 8 16 0 39 8 % D
% Glu: 0 0 0 8 8 8 8 8 0 8 8 8 0 0 0 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 8 0 0 0 0 16 0 8 0 0 47 8 8 % G
% His: 0 0 0 24 0 0 0 0 0 0 0 0 0 8 8 % H
% Ile: 0 0 0 0 0 0 0 0 24 0 8 8 8 0 0 % I
% Lys: 0 0 16 8 0 0 8 0 8 0 16 0 0 8 39 % K
% Leu: 16 8 16 0 62 16 16 0 24 0 8 8 8 8 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 8 8 8 8 0 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 0 39 0 8 0 16 0 8 24 31 16 8 8 % Q
% Arg: 8 0 8 16 0 0 8 8 0 39 0 8 8 8 0 % R
% Ser: 0 16 0 0 0 8 0 47 0 8 0 0 8 0 8 % S
% Thr: 8 0 39 0 8 16 0 0 8 8 8 0 0 8 0 % T
% Val: 47 0 8 0 0 24 62 0 16 8 24 8 8 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 16 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _