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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLH All Species: 7.88
Human Site: S437 Identified Species: 14.44
UniProt: Q9Y253 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y253 NP_006493.1 713 78413 S437 S A S A P S S S T D I T S F L
Chimpanzee Pan troglodytes XP_518497 713 78354 S437 S A S A P S S S T D I T S F L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532150 712 78332 C437 S A P A P S S C T D I T T F L
Cat Felis silvestris
Mouse Mus musculus Q9JJN0 694 76148 L418 Q T E W S P P L T M L F L C A
Rat Rattus norvegicus NP_001101674 689 75727 W414 T S G V Q T E W S P P L T M L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516192 729 78058 G437 Y A P A P P P G A S I T S F L
Chicken Gallus gallus NP_001001304 673 73621 I398 F N D A F A L I Q N C N M A G
Frog Xenopus laevis NP_001087074 684 75120 F405 A F V L L K S F N A A G M H Q
Zebra Danio Brachydanio rerio NP_001035337 743 82024 S436 F S D A P S S S S A G I T G F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649371 885 99008 S452 V G K F E T V S S G Q N K L Q
Honey Bee Apis mellifera XP_001122310 429 48500 E154 T F V V G Y S E I G K N D E E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797437 822 90146 K427 F V E G G S S K L G S I Q S F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568638 672 73967 D396 G V T K I Q E D A F N L F Q A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.2 N.A. 79.6 77.6 N.A. 64.4 51.8 53.1 46.7 N.A. 31.2 27.9 N.A. 38.5
Protein Similarity: 100 99.7 N.A. 90.8 N.A. 85.9 85.1 N.A. 73.6 68 67.7 61.5 N.A. 48.4 40.3 N.A. 55.6
P-Site Identity: 100 100 N.A. 80 N.A. 6.6 6.6 N.A. 53.3 6.6 6.6 33.3 N.A. 6.6 6.6 N.A. 13.3
P-Site Similarity: 100 100 N.A. 86.6 N.A. 13.3 40 N.A. 53.3 20 13.3 53.3 N.A. 20 13.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 31.7 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 31 0 47 0 8 0 0 16 16 8 0 0 8 16 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 8 0 0 8 0 % C
% Asp: 0 0 16 0 0 0 0 8 0 24 0 0 8 0 0 % D
% Glu: 0 0 16 0 8 0 16 8 0 0 0 0 0 8 8 % E
% Phe: 24 16 0 8 8 0 0 8 0 8 0 8 8 31 16 % F
% Gly: 8 8 8 8 16 0 0 8 0 24 8 8 0 8 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 8 0 0 8 8 0 31 16 0 0 0 % I
% Lys: 0 0 8 8 0 8 0 8 0 0 8 0 8 0 0 % K
% Leu: 0 0 0 8 8 0 8 8 8 0 8 16 8 8 39 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 16 8 0 % M
% Asn: 0 8 0 0 0 0 0 0 8 8 8 24 0 0 0 % N
% Pro: 0 0 16 0 39 16 16 0 0 8 8 0 0 0 0 % P
% Gln: 8 0 0 0 8 8 0 0 8 0 8 0 8 8 16 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 24 16 16 0 8 39 54 31 24 8 8 0 24 8 0 % S
% Thr: 16 8 8 0 0 16 0 0 31 0 0 31 24 0 0 % T
% Val: 8 16 16 16 0 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _