Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLH All Species: 11.52
Human Site: S459 Identified Species: 21.11
UniProt: Q9Y253 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y253 NP_006493.1 713 78413 S459 P K V P V T S S E A K T Q G S
Chimpanzee Pan troglodytes XP_518497 713 78354 S459 P K V P V T S S E A K T Q G S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532150 712 78332 S459 T N V P V S S S E A K T Q G C
Cat Felis silvestris
Mouse Mus musculus Q9JJN0 694 76148 T440 P P A C T D I T A F L S S D S
Rat Rattus norvegicus NP_001101674 689 75727 C436 S A S A P P A C T D I T V F L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516192 729 78058 P459 Q K A G A P S P D A G P P G S
Chicken Gallus gallus NP_001001304 673 73621 L420 P P L I S V H L A A S K F S A
Frog Xenopus laevis NP_001087074 684 75120 S427 T L L Q L S A S K F S S T E L
Zebra Danio Brachydanio rerio NP_001035337 743 82024 E458 S P S Q S S M E R P A Q K R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649371 885 99008 G474 A K K R R V S G D E P G Q L P
Honey Bee Apis mellifera XP_001122310 429 48500 E176 I W I K N I F E E F E D I E A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797437 822 90146 E449 P A T A L L K E D Q Q E G L G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568638 672 73967 G418 S F G I K P Q G N K L E T W R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.2 N.A. 79.6 77.6 N.A. 64.4 51.8 53.1 46.7 N.A. 31.2 27.9 N.A. 38.5
Protein Similarity: 100 99.7 N.A. 90.8 N.A. 85.9 85.1 N.A. 73.6 68 67.7 61.5 N.A. 48.4 40.3 N.A. 55.6
P-Site Identity: 100 100 N.A. 73.3 N.A. 13.3 6.6 N.A. 33.3 13.3 6.6 0 N.A. 20 6.6 N.A. 6.6
P-Site Similarity: 100 100 N.A. 80 N.A. 26.6 13.3 N.A. 40 26.6 46.6 13.3 N.A. 26.6 26.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 31.7 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 16 16 16 8 0 16 0 16 39 8 0 0 0 16 % A
% Cys: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 8 % C
% Asp: 0 0 0 0 0 8 0 0 24 8 0 8 0 8 0 % D
% Glu: 0 0 0 0 0 0 0 24 31 8 8 16 0 16 0 % E
% Phe: 0 8 0 0 0 0 8 0 0 24 0 0 8 8 0 % F
% Gly: 0 0 8 8 0 0 0 16 0 0 8 8 8 31 8 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 8 16 0 8 8 0 0 0 8 0 8 0 0 % I
% Lys: 0 31 8 8 8 0 8 0 8 8 24 8 8 0 8 % K
% Leu: 0 8 16 0 16 8 0 8 0 0 16 0 0 16 16 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 8 0 0 0 8 0 0 0 0 0 0 % N
% Pro: 39 24 0 24 8 24 0 8 0 8 8 8 8 0 8 % P
% Gln: 8 0 0 16 0 0 8 0 0 8 8 8 31 0 0 % Q
% Arg: 0 0 0 8 8 0 0 0 8 0 0 0 0 8 8 % R
% Ser: 24 0 16 0 16 24 39 31 0 0 16 16 8 8 31 % S
% Thr: 16 0 8 0 8 16 0 8 8 0 0 31 16 0 0 % T
% Val: 0 0 24 0 24 16 0 0 0 0 0 0 8 0 0 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _