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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLH All Species: 12.42
Human Site: S497 Identified Species: 22.78
UniProt: Q9Y253 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y253 NP_006493.1 713 78413 S497 R Q K V K E A S L S S L T A P
Chimpanzee Pan troglodytes XP_518497 713 78354 S497 R Q K V K E A S L S S L T A P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532150 712 78332 S497 K Q K V K E A S L S S L T A T
Cat Felis silvestris
Mouse Mus musculus Q9JJN0 694 76148 S478 T S K E A A T S L A S F F Q K
Rat Rattus norvegicus NP_001101674 689 75727 E474 P A A P T S K E A A T S L E S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516192 729 78058 L497 K Q R A R E A L L T S P P A P
Chicken Gallus gallus NP_001001304 673 73621 S458 G S T E A T S S T R P R V K F
Frog Xenopus laevis NP_001087074 684 75120 E465 P R R S S A T E T S S P K T P
Zebra Danio Brachydanio rerio NP_001035337 743 82024 S496 E K Q E I Q N S L C P G D Q R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649371 885 99008 D512 L Q G A K K E D A K A D G I S
Honey Bee Apis mellifera XP_001122310 429 48500 Q214 K C S A G I A Q N K I L A K L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797437 822 90146 Q487 P K Q E T V D Q Q T G A G S S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568638 672 73967 V456 Y F Q S Q P T V P S R S A D G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.2 N.A. 79.6 77.6 N.A. 64.4 51.8 53.1 46.7 N.A. 31.2 27.9 N.A. 38.5
Protein Similarity: 100 99.7 N.A. 90.8 N.A. 85.9 85.1 N.A. 73.6 68 67.7 61.5 N.A. 48.4 40.3 N.A. 55.6
P-Site Identity: 100 100 N.A. 86.6 N.A. 26.6 0 N.A. 46.6 6.6 20 13.3 N.A. 13.3 13.3 N.A. 0
P-Site Similarity: 100 100 N.A. 93.3 N.A. 33.3 13.3 N.A. 73.3 13.3 33.3 33.3 N.A. 26.6 20 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 31.7 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 24 16 16 39 0 16 16 8 8 16 31 0 % A
% Cys: 0 8 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 8 0 0 0 8 8 8 0 % D
% Glu: 8 0 0 31 0 31 8 16 0 0 0 0 0 8 0 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 8 8 0 8 % F
% Gly: 8 0 8 0 8 0 0 0 0 0 8 8 16 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 8 0 0 0 0 8 0 0 8 0 % I
% Lys: 24 16 31 0 31 8 8 0 0 16 0 0 8 16 8 % K
% Leu: 8 0 0 0 0 0 0 8 47 0 0 31 8 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % N
% Pro: 24 0 0 8 0 8 0 0 8 0 16 16 8 0 31 % P
% Gln: 0 39 24 0 8 8 0 16 8 0 0 0 0 16 0 % Q
% Arg: 16 8 16 0 8 0 0 0 0 8 8 8 0 0 8 % R
% Ser: 0 16 8 16 8 8 8 47 0 39 47 16 0 8 24 % S
% Thr: 8 0 8 0 16 8 24 0 16 16 8 0 24 8 8 % T
% Val: 0 0 0 24 0 8 0 8 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _