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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLH All Species: 23.94
Human Site: T236 Identified Species: 43.89
UniProt: Q9Y253 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y253 NP_006493.1 713 78413 T236 L N K P N R Q T L V S H G S V
Chimpanzee Pan troglodytes XP_518497 713 78354 T236 L N K P N R Q T L V S H G S V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532150 712 78332 T236 L N K P N R Q T L V S H G S V
Cat Felis silvestris
Mouse Mus musculus Q9JJN0 694 76148 K223 S H N K V L A K L A C G L N K
Rat Rattus norvegicus NP_001101674 689 75727 A222 I S H N K V L A K L A C G L N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516192 729 78058 T236 L N K P N R Q T L L S H G F V
Chicken Gallus gallus NP_001001304 673 73621 A205 I R V A V E K A T G F R C S A
Frog Xenopus laevis NP_001087074 684 75120 S212 E E T T F Q C S A G I A H N K
Zebra Danio Brachydanio rerio NP_001035337 743 82024 T235 L N K P N R Q T V L P L S S V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649371 885 99008 T251 M N K P N K Q T I L P L T E T
Honey Bee Apis mellifera XP_001122310 429 48500
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797437 822 90146 S226 F H K P N R Q S V L P P E G L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568638 672 73967 E202 L R K Q V L K E T E F T C S A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.2 N.A. 79.6 77.6 N.A. 64.4 51.8 53.1 46.7 N.A. 31.2 27.9 N.A. 38.5
Protein Similarity: 100 99.7 N.A. 90.8 N.A. 85.9 85.1 N.A. 73.6 68 67.7 61.5 N.A. 48.4 40.3 N.A. 55.6
P-Site Identity: 100 100 N.A. 100 N.A. 6.6 6.6 N.A. 86.6 6.6 0 66.6 N.A. 40 0 N.A. 33.3
P-Site Similarity: 100 100 N.A. 100 N.A. 20 33.3 N.A. 93.3 20 20 80 N.A. 66.6 0 N.A. 66.6
Percent
Protein Identity: N.A. N.A. N.A. 31.7 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 8 16 8 8 8 8 0 0 16 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 8 8 16 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 8 0 0 0 8 0 8 0 8 0 0 8 8 0 % E
% Phe: 8 0 0 0 8 0 0 0 0 0 16 0 0 8 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 16 0 8 39 8 0 % G
% His: 0 16 8 0 0 0 0 0 0 0 0 31 8 0 0 % H
% Ile: 16 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % I
% Lys: 0 0 62 8 8 8 16 8 8 0 0 0 0 0 16 % K
% Leu: 47 0 0 0 0 16 8 0 39 39 0 16 8 8 8 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 47 8 8 54 0 0 0 0 0 0 0 0 16 8 % N
% Pro: 0 0 0 54 0 0 0 0 0 0 24 8 0 0 0 % P
% Gln: 0 0 0 8 0 8 54 0 0 0 0 0 0 0 0 % Q
% Arg: 0 16 0 0 0 47 0 0 0 0 0 8 0 0 0 % R
% Ser: 8 8 0 0 0 0 0 16 0 0 31 0 8 47 0 % S
% Thr: 0 0 8 8 0 0 0 47 16 0 0 8 8 0 8 % T
% Val: 0 0 8 0 24 8 0 0 16 24 0 0 0 0 39 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _