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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHKB All Species: 19.7
Human Site: S42 Identified Species: 43.33
UniProt: Q9Y259 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y259 NP_005189.2 395 45271 S42 R R R A S S L S R D A E R R A
Chimpanzee Pan troglodytes XP_001144399 395 45239 S42 R R R A S S L S R D A E R R A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848257 395 45274 S42 R R R G S S L S R D A E R R A
Cat Felis silvestris
Mouse Mus musculus O55229 394 45108 S42 R R R A S S L S R D A Q R R A
Rat Rattus norvegicus O54783 394 45082 S42 R R R S S S L S R D A Q R R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520038 436 47973 P47 P R R G D A L P T D Y N S Q H
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001093482 451 51710 D103 D G R N V D V D P D T R R R A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54352 518 59544 N69 P N P S G S E N K N E N E Q N
Honey Bee Apis mellifera XP_624492 379 44310 H32 Y L H G V W K H V T A E N I I
Nematode Worm Caenorhab. elegans P46558 371 42767 E24 L V I E K V I E F G I D F L G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P20485 582 66298 T90 R A S A T D V T D S L G S T S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 90.3 N.A. 85.8 84.8 N.A. 38.9 N.A. N.A. 52.9 N.A. 20.6 44 27.3 N.A.
Protein Similarity: 100 99.7 N.A. 94.1 N.A. 92.9 92.1 N.A. 49.7 N.A. N.A. 68 N.A. 38 61.7 45.8 N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 93.3 86.6 N.A. 26.6 N.A. N.A. 33.3 N.A. 6.6 13.3 0 N.A.
P-Site Similarity: 100 100 N.A. 93.3 N.A. 100 100 N.A. 40 N.A. N.A. 40 N.A. 40 13.3 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 38.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 37 0 10 0 0 0 0 55 0 0 0 55 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 10 19 0 10 10 64 0 10 0 0 0 % D
% Glu: 0 0 0 10 0 0 10 10 0 0 10 37 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 10 0 0 0 10 0 0 % F
% Gly: 0 10 0 28 10 0 0 0 0 10 0 10 0 0 10 % G
% His: 0 0 10 0 0 0 0 10 0 0 0 0 0 0 10 % H
% Ile: 0 0 10 0 0 0 10 0 0 0 10 0 0 10 10 % I
% Lys: 0 0 0 0 10 0 10 0 10 0 0 0 0 0 0 % K
% Leu: 10 10 0 0 0 0 55 0 0 0 10 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 10 0 0 0 10 0 10 0 19 10 0 10 % N
% Pro: 19 0 10 0 0 0 0 10 10 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 19 0 19 0 % Q
% Arg: 55 55 64 0 0 0 0 0 46 0 0 10 55 55 0 % R
% Ser: 0 0 10 19 46 55 0 46 0 10 0 0 19 0 10 % S
% Thr: 0 0 0 0 10 0 0 10 10 10 10 0 0 10 0 % T
% Val: 0 10 0 0 19 10 19 0 10 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _