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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3L
All Species:
38.18
Human Site:
T459
Identified Species:
60
UniProt:
Q9Y262
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y262
NP_057175.1
564
66727
T459
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Chimpanzee
Pan troglodytes
A5A6M4
564
66678
T459
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Rhesus Macaque
Macaca mulatta
XP_001090065
580
67561
F483
P
N
Y
H
K
E
P
F
L
Q
Q
L
K
V
F
Dog
Lupus familis
XP_850423
564
66678
T459
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZY1
564
66594
T459
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Rat
Rattus norvegicus
NP_001029306
382
45064
T286
R
S
F
L
K
L
Y
T
T
M
P
V
A
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514662
564
66751
T459
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Chicken
Gallus gallus
Q5F428
564
66664
T459
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Frog
Xenopus laevis
Q8AVJ0
562
66504
T457
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Zebra Danio
Brachydanio rerio
Q7T2A5
576
67975
T458
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTU4
539
63205
Y439
T
R
S
Y
L
K
L
Y
T
T
L
P
L
T
K
Honey Bee
Apis mellifera
XP_624438
538
63386
K438
Y
T
T
L
P
L
S
K
L
A
T
F
M
C
S
Nematode Worm
Caenorhab. elegans
Q95QW0
537
62458
Y437
L
R
G
Y
L
K
L
Y
T
T
L
P
T
K
K
Sea Urchin
Strong. purpuratus
XP_795841
550
64272
T445
N
Q
Q
L
V
I
Q
T
I
R
S
F
L
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SB62
474
54448
M378
M
D
E
V
K
T
N
M
F
N
P
T
I
K
S
Conservation
Percent
Protein Identity:
100
99.8
92.5
99.8
N.A.
99.1
67.5
N.A.
98.5
97.8
94.1
89.7
N.A.
53.9
58.3
40.5
62.2
Protein Similarity:
100
99.8
92.5
99.8
N.A.
99.6
67.7
N.A.
99.4
99.4
97.6
94.7
N.A.
71.9
72.1
63.1
75.8
P-Site Identity:
100
100
0
100
N.A.
100
26.6
N.A.
100
100
100
100
N.A.
6.6
20
6.6
66.6
P-Site Similarity:
100
100
20
100
N.A.
100
40
N.A.
100
100
100
100
N.A.
13.3
40
13.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
42.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
60.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
54
0
0
0
0
0
7
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
7
0
0
7
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
7
0
0
0
0
7
7
0
0
67
0
0
7
% F
% Gly:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
60
0
0
0
7
0
0
% I
% Lys:
0
0
0
0
20
14
0
7
0
0
0
0
7
80
14
% K
% Leu:
7
0
0
20
14
67
14
0
14
0
14
7
67
0
67
% L
% Met:
7
0
0
0
0
0
0
7
0
7
0
0
7
0
0
% M
% Asn:
7
7
0
0
0
0
7
0
0
7
0
0
0
0
0
% N
% Pro:
7
0
0
0
7
0
7
0
0
0
14
14
0
0
0
% P
% Gln:
54
60
60
0
54
0
7
0
0
7
7
0
0
0
0
% Q
% Arg:
7
14
0
0
0
0
0
0
0
60
0
0
0
0
0
% R
% Ser:
0
7
7
0
0
0
60
0
0
0
60
0
0
0
14
% S
% Thr:
7
7
7
0
0
7
0
67
20
14
7
7
7
7
0
% T
% Val:
0
0
0
7
7
0
0
0
0
0
0
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
7
14
0
0
7
14
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _