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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3L All Species: 27.27
Human Site: Y45 Identified Species: 42.86
UniProt: Q9Y262 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y262 NP_057175.1 564 66727 Y45 R Q Y E Q Q T Y Q V I P E V I
Chimpanzee Pan troglodytes A5A6M4 564 66678 Y45 R Q Y E Q Q T Y Q V I P E V I
Rhesus Macaque Macaca mulatta XP_001090065 580 67561 Y88 R Q Y E Q Q T Y Q V I P E V I
Dog Lupus familis XP_850423 564 66678 Y45 R Q Y E Q Q T Y Q V I P E V I
Cat Felis silvestris
Mouse Mus musculus Q8QZY1 564 66594 Y45 R Q Y E Q Q T Y Q V I P E V I
Rat Rattus norvegicus NP_001029306 382 45064
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514662 564 66751 Y45 R Q Y E Q Q T Y Q V I P E V I
Chicken Gallus gallus Q5F428 564 66664 Y45 R Q Y E Q Q T Y Q V I P E V I
Frog Xenopus laevis Q8AVJ0 562 66504 P47 Q Q T Y Q V I P E V I K N F I
Zebra Danio Brachydanio rerio Q7T2A5 576 67975 I47 H Q Q T Y H V I P E V I K N F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VTU4 539 63205 F45 M P D N V K Y F L I N F C Q A
Honey Bee Apis mellifera XP_624438 538 63386 N45 N F L V F L R N C I N E G M I
Nematode Worm Caenorhab. elegans Q95QW0 537 62458 R45 D Y L V Y F S R M V D E Q N V
Sea Urchin Strong. purpuratus XP_795841 550 64272 G45 G E D F S R R G A N P T Y I V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SB62 474 54448
Conservation
Percent
Protein Identity: 100 99.8 92.5 99.8 N.A. 99.1 67.5 N.A. 98.5 97.8 94.1 89.7 N.A. 53.9 58.3 40.5 62.2
Protein Similarity: 100 99.8 92.5 99.8 N.A. 99.6 67.7 N.A. 99.4 99.4 97.6 94.7 N.A. 71.9 72.1 63.1 75.8
P-Site Identity: 100 100 100 100 N.A. 100 0 N.A. 100 100 33.3 6.6 N.A. 0 6.6 6.6 0
P-Site Similarity: 100 100 100 100 N.A. 100 0 N.A. 100 100 46.6 20 N.A. 20 20 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 42.5
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 60.8
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 0 7 0 0 % C
% Asp: 7 0 14 0 0 0 0 0 0 0 7 0 0 0 0 % D
% Glu: 0 7 0 47 0 0 0 0 7 7 0 14 47 0 0 % E
% Phe: 0 7 0 7 7 7 0 7 0 0 0 7 0 7 7 % F
% Gly: 7 0 0 0 0 0 0 7 0 0 0 0 7 0 0 % G
% His: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 7 7 0 14 54 7 0 7 60 % I
% Lys: 0 0 0 0 0 7 0 0 0 0 0 7 7 0 0 % K
% Leu: 0 0 14 0 0 7 0 0 7 0 0 0 0 0 0 % L
% Met: 7 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % M
% Asn: 7 0 0 7 0 0 0 7 0 7 14 0 7 14 0 % N
% Pro: 0 7 0 0 0 0 0 7 7 0 7 47 0 0 0 % P
% Gln: 7 60 7 0 54 47 0 0 47 0 0 0 7 7 0 % Q
% Arg: 47 0 0 0 0 7 14 7 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 7 0 7 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 7 7 0 0 47 0 0 0 0 7 0 0 0 % T
% Val: 0 0 0 14 7 7 7 0 0 60 7 0 0 47 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 47 7 14 0 7 47 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _