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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CFL2
All Species:
38.18
Human Site:
T148
Identified Species:
70
UniProt:
Q9Y281
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y281
NP_068733.1
166
18737
T148
D
D
I
K
D
R
S
T
L
G
E
K
L
G
G
Chimpanzee
Pan troglodytes
XP_509898
289
31289
T271
D
D
I
K
D
R
S
T
L
G
E
K
L
G
G
Rhesus Macaque
Macaca mulatta
XP_001082579
317
33147
T299
D
D
I
K
D
R
S
T
L
G
E
K
L
G
G
Dog
Lupus familis
XP_851281
242
25771
T166
E
E
V
K
D
H
C
T
L
A
E
K
L
G
D
Cat
Felis silvestris
Mouse
Mus musculus
P45591
166
18691
T148
D
D
I
K
D
R
S
T
L
G
E
K
L
G
G
Rat
Rattus norvegicus
P45592
166
18514
T148
E
E
V
K
D
R
C
T
L
A
E
K
L
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512147
253
27590
T235
D
D
I
K
D
R
S
T
L
G
E
K
L
G
G
Chicken
Gallus gallus
P21566
166
18643
T148
D
D
I
K
D
R
S
T
L
G
E
K
L
G
G
Frog
Xenopus laevis
Q5XHH8
167
18839
T148
D
D
I
K
D
R
C
T
L
A
D
K
L
G
G
Zebra Danio
Brachydanio rerio
NP_991263
166
18550
T148
D
D
I
Q
D
R
S
T
L
A
E
K
L
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41764
139
15881
Q122
N
G
I
Q
V
E
L
Q
A
T
D
A
S
E
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LQ81
140
16323
A123
G
I
Q
V
E
L
Q
A
T
D
P
S
E
M
S
Baker's Yeast
Sacchar. cerevisiae
Q03048
143
15882
E126
V
Q
G
T
D
F
S
E
V
S
Y
D
S
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57.4
52.3
52.8
N.A.
99.4
81.3
N.A.
64.8
98.1
87.4
89.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
57.4
52.3
60.3
N.A.
100
90.3
N.A.
65.2
99.4
93.4
95.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
53.3
N.A.
100
66.6
N.A.
100
100
80
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
73.3
N.A.
100
86.6
N.A.
100
100
86.6
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
31.9
N.A.
30.7
36.7
N.A.
Protein Similarity:
N.A.
46.9
N.A.
54.2
53.6
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
8
31
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
24
0
0
0
0
0
0
0
0
% C
% Asp:
62
62
0
0
85
0
0
0
0
8
16
8
0
0
8
% D
% Glu:
16
16
0
0
8
8
0
8
0
0
70
0
8
8
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
8
0
0
0
0
0
0
47
0
0
0
77
70
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
70
0
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
0
0
0
70
0
0
0
0
0
0
0
77
0
0
0
% K
% Leu:
0
0
0
0
0
8
8
0
77
0
0
0
77
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
8
8
16
0
0
8
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
70
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
62
0
0
8
0
8
16
0
8
% S
% Thr:
0
0
0
8
0
0
0
77
8
8
0
0
0
0
0
% T
% Val:
8
0
16
8
8
0
0
0
8
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _