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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK3
All Species:
12.73
Human Site:
S1226
Identified Species:
28
UniProt:
Q9Y2K2
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2K2
NP_079440.2
1263
139980
S1226
G
H
E
H
P
D
L
S
D
G
S
Q
H
L
N
Chimpanzee
Pan troglodytes
XP_508771
1263
139874
S1226
G
H
E
H
P
D
L
S
D
G
S
Q
H
L
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536563
1290
143819
T1253
G
H
E
H
P
D
L
T
D
G
S
Q
H
L
N
Cat
Felis silvestris
Mouse
Mus musculus
Q6P4S6
1311
145765
D1275
H
E
H
P
G
L
G
D
G
S
Q
H
L
N
S
Rat
Rattus norvegicus
Q9R1U5
776
84890
Q740
L
P
T
G
P
L
P
Q
C
L
T
R
L
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517352
1230
134087
S1193
A
S
D
P
A
G
G
S
S
G
N
Q
H
L
N
Chicken
Gallus gallus
Q9IA88
798
88848
Q762
G
T
T
F
S
Q
Q
Q
S
F
S
A
Q
S
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
D1150
Q
R
E
G
P
V
C
D
V
D
A
D
V
H
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
T1352
T
V
K
C
K
P
T
T
P
H
G
H
S
L
D
Honey Bee
Apis mellifera
XP_395722
901
98876
V865
G
V
Q
I
E
L
R
V
C
E
S
E
E
K
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798437
1066
118092
Q1030
L
P
A
M
I
P
S
Q
L
Q
Q
Q
A
Q
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
89
N.A.
88.4
28.5
N.A.
70.9
29.5
N.A.
58.4
N.A.
26.9
32.2
N.A.
30.7
Protein Similarity:
100
99.8
N.A.
92.1
N.A.
91.7
40.6
N.A.
76.8
43.5
N.A.
69.6
N.A.
38.6
44.9
N.A.
46
P-Site Identity:
100
100
N.A.
93.3
N.A.
0
6.6
N.A.
40
13.3
N.A.
13.3
N.A.
6.6
13.3
N.A.
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
6.6
20
N.A.
53.3
13.3
N.A.
26.6
N.A.
26.6
26.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
10
0
0
0
0
0
10
10
10
0
0
% A
% Cys:
0
0
0
10
0
0
10
0
19
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
28
0
19
28
10
0
10
0
0
10
% D
% Glu:
0
10
37
0
10
0
0
0
0
10
0
10
10
0
19
% E
% Phe:
0
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
46
0
0
19
10
10
19
0
10
37
10
0
0
0
0
% G
% His:
10
28
10
28
0
0
0
0
0
10
0
19
37
10
0
% H
% Ile:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
10
0
10
0
0
0
0
0
0
0
0
10
0
% K
% Leu:
19
0
0
0
0
28
28
0
10
10
0
0
19
46
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
37
% N
% Pro:
0
19
0
19
46
19
10
0
10
0
0
0
0
0
19
% P
% Gln:
10
0
10
0
0
10
10
28
0
10
19
46
10
10
0
% Q
% Arg:
0
10
0
0
0
0
10
0
0
0
0
10
0
0
0
% R
% Ser:
0
10
0
0
10
0
10
28
19
10
46
0
10
19
19
% S
% Thr:
10
10
19
0
0
0
10
19
0
0
10
0
0
0
0
% T
% Val:
0
19
0
0
0
10
0
10
10
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _