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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK3
All Species:
19.09
Human Site:
S219
Identified Species:
42
UniProt:
Q9Y2K2
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2K2
NP_079440.2
1263
139980
S219
N
L
R
A
R
V
L
S
G
K
F
R
I
P
F
Chimpanzee
Pan troglodytes
XP_508771
1263
139874
S219
N
L
R
A
R
V
L
S
G
K
F
R
I
P
F
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536563
1290
143819
S202
N
L
R
A
R
V
L
S
G
K
F
R
I
P
F
Cat
Felis silvestris
Mouse
Mus musculus
Q6P4S6
1311
145765
S219
N
L
R
A
R
V
L
S
G
K
F
R
I
P
F
Rat
Rattus norvegicus
Q9R1U5
776
84890
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517352
1230
134087
F174
L
G
E
P
D
P
N
F
D
R
L
I
A
E
C
Chicken
Gallus gallus
Q9IA88
798
88848
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
S241
G
P
K
V
D
I
W
S
L
G
V
V
L
Y
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
S352
S
L
R
D
R
V
L
S
G
R
F
R
I
P
F
Honey Bee
Apis mellifera
XP_395722
901
98876
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798437
1066
118092
A123
A
E
N
L
L
L
D
A
N
M
N
V
K
I
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
89
N.A.
88.4
28.5
N.A.
70.9
29.5
N.A.
58.4
N.A.
26.9
32.2
N.A.
30.7
Protein Similarity:
100
99.8
N.A.
92.1
N.A.
91.7
40.6
N.A.
76.8
43.5
N.A.
69.6
N.A.
38.6
44.9
N.A.
46
P-Site Identity:
100
100
N.A.
100
N.A.
100
0
N.A.
0
0
N.A.
6.6
N.A.
80
0
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
0
N.A.
6.6
0
N.A.
26.6
N.A.
93.3
0
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
37
0
0
0
10
0
0
0
0
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% C
% Asp:
0
0
0
10
19
0
10
0
10
0
0
0
0
0
0
% D
% Glu:
0
10
10
0
0
0
0
0
0
0
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
46
0
0
0
46
% F
% Gly:
10
10
0
0
0
0
0
0
46
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
0
0
10
46
10
0
% I
% Lys:
0
0
10
0
0
0
0
0
0
37
0
0
10
0
0
% K
% Leu:
10
46
0
10
10
10
46
0
10
0
10
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
37
0
10
0
0
0
10
0
10
0
10
0
0
0
0
% N
% Pro:
0
10
0
10
0
10
0
0
0
0
0
0
0
46
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
46
0
46
0
0
0
0
19
0
46
0
0
0
% R
% Ser:
10
0
0
0
0
0
0
55
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
10
0
46
0
0
0
0
10
19
0
0
10
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _