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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK3
All Species:
15.45
Human Site:
S746
Identified Species:
34
UniProt:
Q9Y2K2
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2K2
NP_079440.2
1263
139980
S746
G
M
Q
Q
P
A
Q
S
Q
Q
V
T
I
Q
V
Chimpanzee
Pan troglodytes
XP_508771
1263
139874
S746
G
M
Q
Q
P
A
Q
S
Q
Q
V
T
I
Q
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536563
1290
143819
S777
G
I
Q
Q
P
P
Q
S
Q
Q
V
T
I
Q
V
Cat
Felis silvestris
Mouse
Mus musculus
Q6P4S6
1311
145765
S794
G
L
Q
Q
A
S
Q
S
Q
P
V
T
I
Q
L
Rat
Rattus norvegicus
Q9R1U5
776
84890
A270
P
A
K
R
I
T
I
A
Q
I
R
Q
H
R
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517352
1230
134087
Q700
Q
Q
V
T
I
Q
V
Q
E
P
A
D
M
L
G
Chicken
Gallus gallus
Q9IA88
798
88848
S292
Q
Q
Q
S
L
S
F
S
M
Q
N
Y
N
S
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
G680
Q
A
L
S
L
G
H
G
E
N
Q
P
S
S
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
S867
G
G
P
T
S
H
S
S
S
D
L
T
R
L
V
Honey Bee
Apis mellifera
XP_395722
901
98876
R395
T
P
Y
H
T
T
R
R
H
T
V
G
P
G
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798437
1066
118092
P560
D
E
N
S
D
G
E
P
D
E
E
A
I
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
89
N.A.
88.4
28.5
N.A.
70.9
29.5
N.A.
58.4
N.A.
26.9
32.2
N.A.
30.7
Protein Similarity:
100
99.8
N.A.
92.1
N.A.
91.7
40.6
N.A.
76.8
43.5
N.A.
69.6
N.A.
38.6
44.9
N.A.
46
P-Site Identity:
100
100
N.A.
86.6
N.A.
66.6
6.6
N.A.
0
20
N.A.
0
N.A.
26.6
6.6
N.A.
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
86.6
33.3
N.A.
13.3
26.6
N.A.
6.6
N.A.
33.3
13.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
0
0
10
19
0
10
0
0
10
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
10
0
0
0
10
10
0
10
0
0
10
% D
% Glu:
0
10
0
0
0
0
10
0
19
10
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
46
10
0
0
0
19
0
10
0
0
0
10
0
10
10
% G
% His:
0
0
0
10
0
10
10
0
10
0
0
0
10
0
10
% H
% Ile:
0
10
0
0
19
0
10
0
0
10
0
0
46
0
0
% I
% Lys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
10
0
19
0
0
0
0
0
10
0
0
19
10
% L
% Met:
0
19
0
0
0
0
0
0
10
0
0
0
10
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
10
10
0
10
0
10
% N
% Pro:
10
10
10
0
28
10
0
10
0
19
0
10
10
0
0
% P
% Gln:
28
19
46
37
0
10
37
10
46
37
10
10
0
37
0
% Q
% Arg:
0
0
0
10
0
0
10
10
0
0
10
0
10
19
10
% R
% Ser:
0
0
0
28
10
19
10
55
10
0
0
0
10
19
0
% S
% Thr:
10
0
0
19
10
19
0
0
0
10
0
46
0
0
0
% T
% Val:
0
0
10
0
0
0
10
0
0
0
46
0
0
0
37
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _