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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 14.55
Human Site: S164 Identified Species: 20
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S164 N E H L K K M S A D N Q L Q V
Chimpanzee Pan troglodytes XP_509678 958 109081 S164 N E H L K K M S A D N Q L Q V
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S154 N E H L K K M S A D N H L Q V
Dog Lupus familis XP_542610 1186 133310 S392 N E H L K K M S A E N H L Q V
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 A164 N E H L K R V A A D S Q L Q V
Rat Rattus norvegicus Q5U2P0 1054 120741 H153 S A V W Y Y H H C E D R M P I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 K171 N D H L K K I K A E D N P P H
Chicken Gallus gallus XP_417016 963 109342 E167 H L K K I Q N E E N E D I Q V
Frog Xenopus laevis Q6GN11 1040 119148 I154 Y Q H C Q K K I P V V M V T E
Zebra Danio Brachydanio rerio A2RV18 1057 120333 N149 N A A V W Y Y N H L A G L Q P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 Q162 D D H L Q A S Q S S K E F E R
Honey Bee Apis mellifera XP_397381 980 112421 L145 W Y N A H L N L D P V K I K T
Nematode Worm Caenorhab. elegans Q17632 961 108768 H172 L K T H W Q K H N V A P V V L
Sea Urchin Strong. purpuratus XP_787332 1412 160533 F285 L A W Y D E H F K D T P I K I
Poplar Tree Populus trichocarpa XP_002303419 935 105261 V153 Q S H L G E A V K V L L I T N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 S150 Q K H L G D T S Q V L L V T N
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 L185 C Q W Y S E H L K P Y D I N V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 93.3 86.6 N.A. 73.3 0 N.A. 40 13.3 13.3 20 N.A. 13.3 0 0 6.6
P-Site Similarity: 100 100 93.3 93.3 N.A. 100 40 N.A. 66.6 40 33.3 33.3 N.A. 53.3 26.6 26.6 33.3
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 13.3 N.A. N.A. 20 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 18 6 6 0 6 6 6 36 0 12 0 0 0 0 % A
% Cys: 6 0 0 6 0 0 0 0 6 0 0 0 0 0 0 % C
% Asp: 6 12 0 0 6 6 0 0 6 30 12 12 0 0 0 % D
% Glu: 0 30 0 0 0 18 0 6 6 18 6 6 0 6 6 % E
% Phe: 0 0 0 0 0 0 0 6 0 0 0 0 6 0 0 % F
% Gly: 0 0 0 0 12 0 0 0 0 0 0 6 0 0 0 % G
% His: 6 0 59 6 6 0 18 12 6 0 0 12 0 0 6 % H
% Ile: 0 0 0 0 6 0 6 6 0 0 0 0 30 0 12 % I
% Lys: 0 12 6 6 36 36 12 6 18 0 6 6 0 12 0 % K
% Leu: 12 6 0 53 0 6 0 12 0 6 12 12 36 0 6 % L
% Met: 0 0 0 0 0 0 24 0 0 0 0 6 6 0 0 % M
% Asn: 42 0 6 0 0 0 12 6 6 6 24 6 0 6 12 % N
% Pro: 0 0 0 0 0 0 0 0 6 12 0 12 6 12 6 % P
% Gln: 12 12 0 0 12 12 0 6 6 0 0 18 0 42 0 % Q
% Arg: 0 0 0 0 0 6 0 0 0 0 0 6 0 0 6 % R
% Ser: 6 6 0 0 6 0 6 30 6 6 6 0 0 0 0 % S
% Thr: 0 0 6 0 0 0 6 0 0 0 6 0 0 18 6 % T
% Val: 0 0 6 6 0 0 6 6 0 24 12 0 18 6 42 % V
% Trp: 6 0 12 6 12 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 6 6 0 12 6 12 6 0 0 0 6 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _