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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
14.55
Human Site:
S164
Identified Species:
20
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
S164
N
E
H
L
K
K
M
S
A
D
N
Q
L
Q
V
Chimpanzee
Pan troglodytes
XP_509678
958
109081
S164
N
E
H
L
K
K
M
S
A
D
N
Q
L
Q
V
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
S154
N
E
H
L
K
K
M
S
A
D
N
H
L
Q
V
Dog
Lupus familis
XP_542610
1186
133310
S392
N
E
H
L
K
K
M
S
A
E
N
H
L
Q
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
A164
N
E
H
L
K
R
V
A
A
D
S
Q
L
Q
V
Rat
Rattus norvegicus
Q5U2P0
1054
120741
H153
S
A
V
W
Y
Y
H
H
C
E
D
R
M
P
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
K171
N
D
H
L
K
K
I
K
A
E
D
N
P
P
H
Chicken
Gallus gallus
XP_417016
963
109342
E167
H
L
K
K
I
Q
N
E
E
N
E
D
I
Q
V
Frog
Xenopus laevis
Q6GN11
1040
119148
I154
Y
Q
H
C
Q
K
K
I
P
V
V
M
V
T
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
N149
N
A
A
V
W
Y
Y
N
H
L
A
G
L
Q
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
Q162
D
D
H
L
Q
A
S
Q
S
S
K
E
F
E
R
Honey Bee
Apis mellifera
XP_397381
980
112421
L145
W
Y
N
A
H
L
N
L
D
P
V
K
I
K
T
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
H172
L
K
T
H
W
Q
K
H
N
V
A
P
V
V
L
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
F285
L
A
W
Y
D
E
H
F
K
D
T
P
I
K
I
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
V153
Q
S
H
L
G
E
A
V
K
V
L
L
I
T
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
S150
Q
K
H
L
G
D
T
S
Q
V
L
L
V
T
N
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L185
C
Q
W
Y
S
E
H
L
K
P
Y
D
I
N
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
93.3
86.6
N.A.
73.3
0
N.A.
40
13.3
13.3
20
N.A.
13.3
0
0
6.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
100
40
N.A.
66.6
40
33.3
33.3
N.A.
53.3
26.6
26.6
33.3
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
13.3
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
33.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
18
6
6
0
6
6
6
36
0
12
0
0
0
0
% A
% Cys:
6
0
0
6
0
0
0
0
6
0
0
0
0
0
0
% C
% Asp:
6
12
0
0
6
6
0
0
6
30
12
12
0
0
0
% D
% Glu:
0
30
0
0
0
18
0
6
6
18
6
6
0
6
6
% E
% Phe:
0
0
0
0
0
0
0
6
0
0
0
0
6
0
0
% F
% Gly:
0
0
0
0
12
0
0
0
0
0
0
6
0
0
0
% G
% His:
6
0
59
6
6
0
18
12
6
0
0
12
0
0
6
% H
% Ile:
0
0
0
0
6
0
6
6
0
0
0
0
30
0
12
% I
% Lys:
0
12
6
6
36
36
12
6
18
0
6
6
0
12
0
% K
% Leu:
12
6
0
53
0
6
0
12
0
6
12
12
36
0
6
% L
% Met:
0
0
0
0
0
0
24
0
0
0
0
6
6
0
0
% M
% Asn:
42
0
6
0
0
0
12
6
6
6
24
6
0
6
12
% N
% Pro:
0
0
0
0
0
0
0
0
6
12
0
12
6
12
6
% P
% Gln:
12
12
0
0
12
12
0
6
6
0
0
18
0
42
0
% Q
% Arg:
0
0
0
0
0
6
0
0
0
0
0
6
0
0
6
% R
% Ser:
6
6
0
0
6
0
6
30
6
6
6
0
0
0
0
% S
% Thr:
0
0
6
0
0
0
6
0
0
0
6
0
0
18
6
% T
% Val:
0
0
6
6
0
0
6
6
0
24
12
0
18
6
42
% V
% Trp:
6
0
12
6
12
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
6
0
12
6
12
6
0
0
0
6
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _