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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
26.97
Human Site:
S215
Identified Species:
37.08
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
S215
I
D
R
L
A
C
L
S
E
E
G
N
E
I
E
Chimpanzee
Pan troglodytes
XP_509678
958
109081
S215
I
D
R
L
A
C
L
S
E
E
G
N
E
I
E
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
S205
I
D
R
L
A
C
L
S
E
E
V
N
E
I
E
Dog
Lupus familis
XP_542610
1186
133310
S443
I
D
R
L
A
C
L
S
E
E
G
N
E
I
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
S215
I
D
R
L
A
Y
L
S
D
E
M
N
E
I
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
E212
S
I
I
Q
S
R
R
E
R
E
S
E
S
Q
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
S223
V
D
R
L
A
S
I
S
D
E
K
N
E
I
E
Chicken
Gallus gallus
XP_417016
963
109342
S218
V
D
R
L
A
C
V
S
D
E
G
K
E
I
E
Frog
Xenopus laevis
Q6GN11
1040
119148
L225
G
K
E
Y
P
E
H
L
P
L
E
I
L
E
A
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
T206
L
Y
H
S
I
A
Q
T
L
Q
E
R
E
N
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
H219
L
L
M
D
K
L
S
H
K
T
F
D
S
E
K
Honey Bee
Apis mellifera
XP_397381
980
112421
K194
F
L
S
D
K
L
C
K
K
S
Y
G
M
V
S
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
A220
A
L
L
D
Q
M
A
A
Y
E
S
S
G
N
G
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
D346
E
R
E
R
K
A
N
D
S
D
I
T
A
P
G
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
E206
S
E
D
V
I
M
E
E
V
E
D
M
R
P
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
D203
N
E
D
I
T
M
E
D
A
D
D
S
R
P
S
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
D242
I
P
Q
M
D
S
F
D
K
D
L
E
R
D
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
93.3
100
N.A.
80
13.3
N.A.
66.6
73.3
0
6.6
N.A.
0
0
6.6
0
P-Site Similarity:
100
100
93.3
100
N.A.
86.6
20
N.A.
86.6
93.3
0
33.3
N.A.
26.6
13.3
20
6.6
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
0
0
42
12
6
6
6
0
0
0
6
0
6
% A
% Cys:
0
0
0
0
0
30
6
0
0
0
0
0
0
0
0
% C
% Asp:
0
42
12
18
6
0
0
18
18
18
12
6
0
6
6
% D
% Glu:
6
12
12
0
0
6
12
12
24
59
12
12
48
12
48
% E
% Phe:
6
0
0
0
0
0
6
0
0
0
6
0
0
0
0
% F
% Gly:
6
0
0
0
0
0
0
0
0
0
24
6
6
0
12
% G
% His:
0
0
6
0
0
0
6
6
0
0
0
0
0
0
0
% H
% Ile:
36
6
6
6
12
0
6
0
0
0
6
6
0
42
0
% I
% Lys:
0
6
0
0
18
0
0
6
18
0
6
6
0
0
6
% K
% Leu:
12
18
6
42
0
12
30
6
6
6
6
0
6
0
0
% L
% Met:
0
0
6
6
0
18
0
0
0
0
6
6
6
0
0
% M
% Asn:
6
0
0
0
0
0
6
0
0
0
0
36
0
12
0
% N
% Pro:
0
6
0
0
6
0
0
0
6
0
0
0
0
18
0
% P
% Gln:
0
0
6
6
6
0
6
0
0
6
0
0
0
6
0
% Q
% Arg:
0
6
42
6
0
6
6
0
6
0
0
6
18
0
0
% R
% Ser:
12
0
6
6
6
12
6
42
6
6
12
12
12
0
18
% S
% Thr:
0
0
0
0
6
0
0
6
0
6
0
6
0
0
6
% T
% Val:
12
0
0
6
0
0
6
0
6
0
6
0
0
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
6
0
6
0
6
0
0
6
0
6
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _