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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
26.67
Human Site:
S229
Identified Species:
36.67
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
S229
E
S
G
K
I
I
F
S
E
H
L
P
L
S
K
Chimpanzee
Pan troglodytes
XP_509678
958
109081
S229
E
S
G
K
I
I
F
S
E
H
L
P
L
S
K
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
S219
E
S
G
K
I
I
F
S
E
H
L
P
L
S
K
Dog
Lupus familis
XP_542610
1186
133310
S457
E
N
G
R
I
I
F
S
E
H
L
P
L
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
S229
E
S
G
K
I
I
F
S
E
H
L
P
L
S
K
Rat
Rattus norvegicus
Q5U2P0
1054
120741
P226
E
T
H
G
K
E
Y
P
E
H
L
P
L
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
S237
E
S
G
K
I
I
F
S
E
H
L
P
L
S
K
Chicken
Gallus gallus
XP_417016
963
109342
P232
E
S
G
K
I
I
F
P
E
H
I
P
L
S
K
Frog
Xenopus laevis
Q6GN11
1040
119148
Y239
A
G
I
K
S
G
R
Y
K
Q
G
V
L
S
V
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
T220
D
G
A
E
K
V
Y
T
E
H
L
P
A
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
P233
K
N
G
L
P
Q
Y
P
P
H
L
S
M
K
E
Honey Bee
Apis mellifera
XP_397381
980
112421
P208
S
K
G
R
E
F
F
P
C
H
L
T
P
S
E
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
D234
G
N
E
K
Q
I
F
D
E
Y
L
S
H
D
R
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
P360
G
G
R
N
V
L
Y
P
E
H
L
S
S
Y
E
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
P220
S
K
R
K
V
V
Y
P
E
H
K
P
M
S
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
Q217
S
K
R
K
L
I
Y
Q
E
H
K
P
M
S
E
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
P256
T
F
S
D
F
T
F
P
E
Y
Y
S
T
A
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
100
86.6
N.A.
100
40
N.A.
100
86.6
20
26.6
N.A.
20
33.3
33.3
20
P-Site Similarity:
100
100
100
100
N.A.
100
53.3
N.A.
100
93.3
26.6
60
N.A.
53.3
46.6
53.3
46.6
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
33.3
N.A.
N.A.
40
13.3
N.A.
P-Site Similarity:
66.6
N.A.
N.A.
66.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
6
0
0
0
0
0
0
0
0
0
6
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% C
% Asp:
6
0
0
6
0
0
0
6
0
0
0
0
0
6
0
% D
% Glu:
48
0
6
6
6
6
0
0
83
0
0
0
0
12
30
% E
% Phe:
0
6
0
0
6
6
59
0
0
0
0
0
0
0
0
% F
% Gly:
12
18
53
6
0
6
0
0
0
0
6
0
0
0
0
% G
% His:
0
0
6
0
0
0
0
0
0
83
0
0
6
0
0
% H
% Ile:
0
0
6
0
42
53
0
0
0
0
6
0
0
0
0
% I
% Lys:
6
18
0
59
12
0
0
0
6
0
12
0
0
6
42
% K
% Leu:
0
0
0
6
6
6
0
0
0
0
71
0
53
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
18
0
0
% M
% Asn:
0
18
0
6
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
6
0
0
42
6
0
0
65
6
0
0
% P
% Gln:
0
0
0
0
6
6
0
6
0
6
0
0
0
0
0
% Q
% Arg:
0
0
18
12
0
0
6
0
0
0
0
0
0
0
12
% R
% Ser:
18
36
6
0
6
0
0
36
0
0
0
24
6
65
0
% S
% Thr:
6
6
0
0
0
6
0
6
0
0
0
6
6
0
0
% T
% Val:
0
0
0
0
12
12
0
0
0
0
0
6
0
0
18
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
36
6
0
12
6
0
0
6
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _