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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 40
Human Site: S235 Identified Species: 55
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S235 F S E H L P L S K L Q Q G I K
Chimpanzee Pan troglodytes XP_509678 958 109081 S235 F S E H L P L S K L Q Q G I K
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S225 F S E H L P L S K L Q Q G I K
Dog Lupus familis XP_542610 1186 133310 S463 F S E H L P L S K L Q Q G I K
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 S235 F S E H L P L S K L Q Q G I K
Rat Rattus norvegicus Q5U2P0 1054 120741 E232 Y P E H L P L E V L E A G I K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 S243 F S E H L P L S K L Q Q G I K
Chicken Gallus gallus XP_417016 963 109342 S238 F P E H I P L S K L Q Q G I K
Frog Xenopus laevis Q6GN11 1040 119148 S245 R Y K Q G V L S V N K H R A Q
Zebra Danio Brachydanio rerio A2RV18 1057 120333 E226 Y T E H L P A E V L E A G I K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 K239 Y P P H L S M K E L L E G L R
Honey Bee Apis mellifera XP_397381 980 112421 S214 F P C H L T P S E I H D G I K
Nematode Worm Caenorhab. elegans Q17632 961 108768 D240 F D E Y L S H D R I M E G I A
Sea Urchin Strong. purpuratus XP_787332 1412 160533 Y366 Y P E H L S S Y E I N A G I K
Poplar Tree Populus trichocarpa XP_002303419 935 105261 S226 Y P E H K P M S E I T S G L T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 S223 Y Q E H K P M S E I T A G L H
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 A262 F P E Y Y S T A R V M G G L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 100 N.A. 100 60 N.A. 100 86.6 13.3 53.3 N.A. 26.6 46.6 33.3 40
P-Site Similarity: 100 100 100 100 N.A. 100 73.3 N.A. 100 93.3 33.3 73.3 N.A. 66.6 60 60 60
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 33.3 N.A. N.A. 33.3 26.6 N.A.
P-Site Similarity: 66.6 N.A. N.A. 66.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 6 6 0 0 0 24 0 6 6 % A
% Cys: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 6 0 0 0 0 0 6 0 0 0 6 0 0 0 % D
% Glu: 0 0 83 0 0 0 0 12 30 0 12 12 0 0 0 % E
% Phe: 59 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 6 0 0 0 0 0 0 6 95 0 0 % G
% His: 0 0 0 83 0 0 6 0 0 0 6 6 0 0 6 % H
% Ile: 0 0 0 0 6 0 0 0 0 30 0 0 0 71 0 % I
% Lys: 0 0 6 0 12 0 0 6 42 0 6 0 0 0 71 % K
% Leu: 0 0 0 0 71 0 53 0 0 59 6 0 0 24 0 % L
% Met: 0 0 0 0 0 0 18 0 0 0 12 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 6 6 0 0 0 0 % N
% Pro: 0 42 6 0 0 65 6 0 0 0 0 0 0 0 0 % P
% Gln: 0 6 0 6 0 0 0 0 0 0 42 42 0 0 6 % Q
% Arg: 6 0 0 0 0 0 0 0 12 0 0 0 6 0 6 % R
% Ser: 0 36 0 0 0 24 6 65 0 0 0 6 0 0 0 % S
% Thr: 0 6 0 0 0 6 6 0 0 0 12 0 0 0 6 % T
% Val: 0 0 0 0 0 6 0 0 18 6 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 36 6 0 12 6 0 0 6 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _