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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 44.55
Human Site: S254 Identified Species: 61.25
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S254 L Q G T F R A S R E N Y L E A
Chimpanzee Pan troglodytes XP_509678 958 109081 S254 L Q G T F R A S R E N Y L E A
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S244 L Q G T F R A S R E N Y L E A
Dog Lupus familis XP_542610 1186 133310 S482 L Q G T F R A S R E N Y L E A
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 S254 L Q G T F R A S R E N Y L E A
Rat Rattus norvegicus Q5U2P0 1054 120741 N251 I Q G I L N V N K H R A Q I E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 S262 L Q G T F R A S R E N Y L E A
Chicken Gallus gallus XP_417016 963 109342 S257 L Q G T Y R A S R E N Y L E A
Frog Xenopus laevis Q6GN11 1040 119148 G264 V R L Q G L G G K E T D I Q S
Zebra Danio Brachydanio rerio A2RV18 1057 120333 N245 I Q G I L S V N K H R A Q H E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 S258 L Q G T F Q A S R E N Y L E G
Honey Bee Apis mellifera XP_397381 980 112421 S233 L Q G T F I A S K E N F L E G
Nematode Worm Caenorhab. elegans Q17632 961 108768 S259 K R G N F S V S R E N Y R E A
Sea Urchin Strong. purpuratus XP_787332 1412 160533 S385 K K G T F K A S R E N F R E G
Poplar Tree Populus trichocarpa XP_002303419 935 105261 N245 H Q G K L R V N R Y N P F E A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 N242 H Q G K L R V N R F N P Y E A
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 S281 Y Q G N I Q I S E Y N F L E G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. 100 93.3 6.6 13.3 N.A. 86.6 73.3 60 60
P-Site Similarity: 100 100 100 100 N.A. 100 33.3 N.A. 100 100 46.6 33.3 N.A. 93.3 86.6 66.6 80
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 46.6 N.A. N.A. 46.6 40 N.A.
P-Site Similarity: 53.3 N.A. N.A. 53.3 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 59 0 0 0 0 12 0 0 59 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 6 71 0 0 0 83 12 % E
% Phe: 0 0 0 0 59 0 0 0 0 6 0 18 6 0 0 % F
% Gly: 0 0 95 0 6 0 6 6 0 0 0 0 0 0 24 % G
% His: 12 0 0 0 0 0 0 0 0 12 0 0 0 6 0 % H
% Ile: 12 0 0 12 6 6 6 0 0 0 0 0 6 6 0 % I
% Lys: 12 6 0 12 0 6 0 0 24 0 0 0 0 0 0 % K
% Leu: 53 0 6 0 24 6 0 0 0 0 0 0 59 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 12 0 6 0 24 0 0 83 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % P
% Gln: 0 83 0 6 0 12 0 0 0 0 0 0 12 6 0 % Q
% Arg: 0 12 0 0 0 53 0 0 71 0 12 0 12 0 0 % R
% Ser: 0 0 0 0 0 12 0 71 0 0 0 0 0 0 6 % S
% Thr: 0 0 0 59 0 0 0 0 0 0 6 0 0 0 0 % T
% Val: 6 0 0 0 0 0 30 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 6 0 0 0 6 0 0 0 0 12 0 53 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _