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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 21.21
Human Site: S300 Identified Species: 29.17
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S300 A V E L L P K S Q W V A P S S
Chimpanzee Pan troglodytes XP_509678 958 109081 S300 A V E L L P K S Q W V A P S S
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S290 A V E L L P K S Q W V A P S S
Dog Lupus familis XP_542610 1186 133310 N528 A I E L L P K N Q W V A P S S
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 S300 A V E L L P R S Q W V A P S S
Rat Rattus norvegicus Q5U2P0 1054 120741 A284 I L I H G S K A R N R S I H G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 N308 A V E L L A K N Q W V A P S S
Chicken Gallus gallus XP_417016 963 109342 D303 A V E L L A K D E W V A P S S
Frog Xenopus laevis Q6GN11 1040 119148 A291 A I H G D L V A V E L L P K S
Zebra Danio Brachydanio rerio A2RV18 1057 120333 N280 I N G A K H R N R A V H G D V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 A301 A V E L L P E A E W S A P S E
Honey Bee Apis mellifera XP_397381 980 112421 N276 A L E I L P E N Q W S S P S D
Nematode Worm Caenorhab. elegans Q17632 961 108768 D301 A V Q L L P E D Q W T A P E K
Sea Urchin Strong. purpuratus XP_787332 1412 160533 S428 A V E M F A E S Q W T A P S T
Poplar Tree Populus trichocarpa XP_002303419 935 105261 D288 A V E L L P Q D Q W H E E K S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 D285 A V E L L P R D Q W Q D E K A
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 S324 I V E L L P Q S E W K A P S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 86.6 N.A. 93.3 6.6 N.A. 86.6 80 20 6.6 N.A. 66.6 53.3 60 60
P-Site Similarity: 100 100 100 100 N.A. 100 33.3 N.A. 93.3 86.6 40 26.6 N.A. 86.6 86.6 73.3 80
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 60 N.A. N.A. 53.3 73.3 N.A.
P-Site Similarity: 66.6 N.A. N.A. 66.6 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 83 0 0 6 0 18 0 18 0 6 0 65 0 0 6 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 6 0 0 24 0 0 0 6 0 6 6 % D
% Glu: 0 0 77 0 0 0 24 0 18 6 0 6 12 6 6 % E
% Phe: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 6 6 6 0 0 0 0 0 0 0 6 0 6 % G
% His: 0 0 6 6 0 6 0 0 0 0 6 6 0 6 0 % H
% Ile: 18 12 6 6 0 0 0 0 0 0 0 0 6 0 0 % I
% Lys: 0 0 0 0 6 0 42 0 0 0 6 0 0 18 6 % K
% Leu: 0 12 0 71 77 6 0 0 0 0 6 6 0 0 0 % L
% Met: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 6 0 0 0 0 0 24 0 6 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 65 0 0 0 0 0 0 77 0 0 % P
% Gln: 0 0 6 0 0 0 12 0 65 0 6 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 18 0 12 0 6 0 0 0 0 % R
% Ser: 0 0 0 0 0 6 0 36 0 0 12 12 0 65 59 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 12 0 0 0 6 % T
% Val: 0 71 0 0 0 0 6 0 6 0 48 0 0 0 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 83 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _