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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
28.18
Human Site:
S361
Identified Species:
38.75
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
S361
R
P
Y
C
G
M
L
S
K
S
D
I
K
E
S
Chimpanzee
Pan troglodytes
XP_509678
958
109081
S361
R
P
Y
C
G
M
L
S
K
S
D
I
K
E
S
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
S351
R
P
Y
C
G
M
L
S
K
S
D
I
K
E
S
Dog
Lupus familis
XP_542610
1186
133310
S589
R
P
Y
C
G
M
L
S
K
S
D
I
K
E
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
S361
R
P
Y
C
G
M
L
S
K
S
D
I
K
E
S
Rat
Rattus norvegicus
Q5U2P0
1054
120741
V355
T
F
P
S
K
E
E
V
Q
S
Q
G
K
N
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
S369
R
P
F
C
G
M
L
S
K
S
L
I
K
E
A
Chicken
Gallus gallus
XP_417016
963
109342
S364
R
P
F
C
G
M
L
S
K
S
Q
I
K
E
A
Frog
Xenopus laevis
Q6GN11
1040
119148
T350
T
F
P
A
K
E
D
T
E
T
Q
G
K
N
T
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
M349
T
L
P
P
F
E
E
M
Q
S
Q
S
R
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
Q368
R
Q
Y
C
G
I
L
Q
P
S
L
I
E
D
T
Honey Bee
Apis mellifera
XP_397381
980
112421
Q336
R
Q
Y
C
G
I
L
Q
S
N
N
I
E
G
N
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
L370
R
E
Y
C
G
M
L
L
P
S
T
V
K
G
A
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
M485
R
P
F
C
G
V
I
M
P
A
A
V
K
G
G
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
E359
H
S
Y
C
G
S
L
E
P
M
P
M
P
A
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
E357
H
S
Y
C
G
S
L
E
P
M
S
L
P
A
G
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
A408
R
Q
Y
V
G
Q
L
A
P
S
S
V
D
P
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
80
80
6.6
13.3
N.A.
46.6
40
53.3
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
93.3
93.3
33.3
26.6
N.A.
73.3
73.3
66.6
66.6
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
26.6
N.A.
N.A.
26.6
33.3
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
33.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
6
0
0
0
6
0
6
6
0
0
12
24
% A
% Cys:
0
0
0
77
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
6
0
0
0
30
0
6
6
0
% D
% Glu:
0
6
0
0
0
18
12
12
6
0
0
0
12
42
0
% E
% Phe:
0
12
18
0
6
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
83
0
0
0
0
0
0
12
0
18
18
% G
% His:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
6
0
0
0
0
53
0
0
0
% I
% Lys:
0
0
0
0
12
0
0
0
42
0
0
0
65
0
0
% K
% Leu:
0
6
0
0
0
0
77
6
0
0
12
6
0
0
0
% L
% Met:
0
0
0
0
0
48
0
12
0
12
0
6
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
6
6
0
0
18
6
% N
% Pro:
0
48
18
6
0
0
0
0
36
0
6
0
12
6
0
% P
% Gln:
0
18
0
0
0
6
0
12
12
0
24
0
0
0
6
% Q
% Arg:
71
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% R
% Ser:
0
12
0
6
0
12
0
42
6
71
12
6
0
0
36
% S
% Thr:
18
0
0
0
0
0
0
6
0
6
6
0
0
0
12
% T
% Val:
0
0
0
6
0
6
0
6
0
0
0
18
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
65
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _