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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 26.36
Human Site: S368 Identified Species: 36.25
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S368 S K S D I K E S R R H L F T P
Chimpanzee Pan troglodytes XP_509678 958 109081 S368 S K S D I K E S R R H L F T P
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S358 S K S D I K E S R R H L F T P
Dog Lupus familis XP_542610 1186 133310 S596 S K S D I K E S R R H L F T P
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 S368 S K S D I K E S R R H L F T P
Rat Rattus norvegicus Q5U2P0 1054 120741 A362 V Q S Q G K N A Q K I L V T P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 A376 S K S L I K E A R R H L F T P
Chicken Gallus gallus XP_417016 963 109342 A371 S K S Q I K E A R R H L F I P
Frog Xenopus laevis Q6GN11 1040 119148 T357 T E T Q G K N T Q K V L V M P
Zebra Danio Brachydanio rerio A2RV18 1057 120333 S356 M Q S Q S R N S Q K I L V V P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 T375 Q P S L I E D T N R H I F V P
Honey Bee Apis mellifera XP_397381 980 112421 N343 Q S N N I E G N V R H V F I P
Nematode Worm Caenorhab. elegans Q17632 961 108768 A377 L P S T V K G A R R H L F C P
Sea Urchin Strong. purpuratus XP_787332 1412 160533 G492 M P A A V K G G T K H L F M A
Poplar Tree Populus trichocarpa XP_002303419 935 105261 G366 E P M P M P A G S G G L V Y A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 G364 E P M S L P A G S G G T A H A
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 Q415 A P S S V D P Q S S S T Q N V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 100 N.A. 100 33.3 N.A. 86.6 80 20 26.6 N.A. 40 33.3 53.3 26.6
P-Site Similarity: 100 100 100 100 N.A. 100 60 N.A. 93.3 86.6 60 53.3 N.A. 66.6 66.6 66.6 46.6
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 6.6 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 13.3 N.A. N.A. 6.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 6 6 0 0 12 24 0 0 0 0 6 0 18 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % C
% Asp: 0 0 0 30 0 6 6 0 0 0 0 0 0 0 0 % D
% Glu: 12 6 0 0 0 12 42 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 65 0 0 % F
% Gly: 0 0 0 0 12 0 18 18 0 12 12 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 65 0 0 6 0 % H
% Ile: 0 0 0 0 53 0 0 0 0 0 12 6 0 12 0 % I
% Lys: 0 42 0 0 0 65 0 0 0 24 0 0 0 0 0 % K
% Leu: 6 0 0 12 6 0 0 0 0 0 0 77 0 0 0 % L
% Met: 12 0 12 0 6 0 0 0 0 0 0 0 0 12 0 % M
% Asn: 0 0 6 6 0 0 18 6 6 0 0 0 0 6 0 % N
% Pro: 0 36 0 6 0 12 6 0 0 0 0 0 0 0 77 % P
% Gln: 12 12 0 24 0 0 0 6 18 0 0 0 6 0 0 % Q
% Arg: 0 0 0 0 0 6 0 0 48 59 0 0 0 0 0 % R
% Ser: 42 6 71 12 6 0 0 36 18 6 6 0 0 0 0 % S
% Thr: 6 0 6 6 0 0 0 12 6 0 0 12 0 42 0 % T
% Val: 6 0 0 0 18 0 0 0 6 0 6 6 24 12 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _