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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
25.45
Human Site:
S391
Identified Species:
35
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
S391
R
I
E
T
R
Q
A
S
T
L
E
G
R
R
I
Chimpanzee
Pan troglodytes
XP_509678
958
109081
S391
R
I
E
T
R
Q
A
S
T
L
E
G
R
R
I
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
S381
R
I
E
T
R
Q
A
S
A
L
E
G
R
R
I
Dog
Lupus familis
XP_542610
1186
133310
S619
R
I
E
T
R
Q
A
S
A
L
E
G
R
R
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
S391
R
I
E
T
R
Q
A
S
A
L
E
G
R
R
I
Rat
Rattus norvegicus
Q5U2P0
1054
120741
E385
R
I
S
T
Q
Q
A
E
A
L
Q
D
F
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
S399
R
I
E
T
R
Q
A
S
T
L
D
G
Q
R
I
Chicken
Gallus gallus
XP_417016
963
109342
D394
R
I
E
T
R
Q
A
D
K
L
E
G
Q
R
I
Frog
Xenopus laevis
Q6GN11
1040
119148
E380
R
I
S
T
Q
Q
A
E
A
L
Q
N
Y
R
V
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
E379
R
I
S
T
Q
Q
A
E
A
L
Q
D
Q
R
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
A398
R
I
E
T
R
Q
A
A
M
L
Q
N
Q
R
I
Honey Bee
Apis mellifera
XP_397381
980
112421
G366
R
I
E
T
R
Q
Y
G
I
L
S
K
Q
R
I
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
E400
R
I
E
T
E
Q
A
E
T
L
S
Q
Q
R
I
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
E515
R
I
E
T
Q
Q
Y
E
T
L
A
G
N
R
I
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
T389
I
P
K
I
R
I
Q
T
R
Q
L
D
N
L
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
T387
I
P
K
I
R
I
N
T
R
Q
L
Q
N
L
L
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
T438
L
P
K
V
R
I
R
T
R
R
A
A
E
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
46.6
N.A.
86.6
80
46.6
46.6
N.A.
66.6
60
66.6
66.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
66.6
N.A.
100
86.6
66.6
73.3
N.A.
86.6
66.6
73.3
73.3
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
71
6
36
0
12
6
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
6
0
0
6
18
0
0
0
% D
% Glu:
0
0
65
0
6
0
0
30
0
0
36
0
6
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% F
% Gly:
0
0
0
0
0
0
0
6
0
0
0
48
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
83
0
12
0
18
0
0
6
0
0
0
0
0
65
% I
% Lys:
0
0
18
0
0
0
0
0
6
0
0
6
0
0
0
% K
% Leu:
6
0
0
0
0
0
0
0
0
83
12
0
0
18
18
% L
% Met:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
6
0
0
0
0
12
18
0
0
% N
% Pro:
0
18
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
24
83
6
0
0
12
24
12
36
0
0
% Q
% Arg:
83
0
0
0
71
0
6
0
18
6
0
0
30
83
0
% R
% Ser:
0
0
18
0
0
0
0
36
0
0
12
0
0
0
0
% S
% Thr:
0
0
0
83
0
0
0
18
30
0
0
0
0
0
0
% T
% Val:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
18
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
12
0
0
0
0
0
6
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _