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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
25.15
Human Site:
S57
Identified Species:
34.58
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
S57
P
Q
P
Q
D
P
A
S
S
V
C
P
Q
P
H
Chimpanzee
Pan troglodytes
XP_509678
958
109081
S57
P
Q
P
Q
D
P
A
S
S
L
C
P
Q
P
H
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
S57
P
Q
P
Q
D
P
A
S
S
L
C
P
Q
P
H
Dog
Lupus familis
XP_542610
1186
133310
T88
S
K
T
G
N
P
S
T
T
P
R
V
R
L
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
S57
L
Q
P
R
D
Q
A
S
S
L
C
P
W
P
H
Rat
Rattus norvegicus
Q5U2P0
1054
120741
L50
T
C
R
N
D
G
K
L
L
S
A
E
V
T
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
S64
P
R
P
R
H
P
H
S
S
L
C
P
Q
P
H
Chicken
Gallus gallus
XP_417016
963
109342
S58
A
R
P
S
G
A
A
S
S
L
C
P
G
P
H
Frog
Xenopus laevis
Q6GN11
1040
119148
L46
T
C
P
R
D
G
K
L
L
S
E
E
L
T
H
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
V47
D
C
Q
N
V
G
K
V
L
S
R
D
V
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
S55
T
S
Q
H
A
N
K
S
T
L
F
K
F
P
H
Honey Bee
Apis mellifera
XP_397381
980
112421
I40
S
K
V
C
E
K
C
I
F
R
I
Q
N
P
H
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
R66
L
K
I
E
N
P
V
R
N
A
K
V
G
R
H
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
T174
I
S
I
Q
E
D
L
T
A
L
N
Q
D
L
Y
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
R46
C
E
D
K
S
K
A
R
L
T
A
T
A
S
T
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
A43
C
K
S
C
D
S
S
A
A
R
L
S
S
S
K
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L79
L
S
D
S
P
L
E
L
S
A
P
I
G
K
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
93.3
93.3
6.6
N.A.
66.6
13.3
N.A.
66.6
53.3
20
6.6
N.A.
20
13.3
13.3
6.6
P-Site Similarity:
100
100
100
46.6
N.A.
80
13.3
N.A.
86.6
66.6
26.6
6.6
N.A.
33.3
26.6
40
40
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
20
N.A.
N.A.
33.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
0
0
6
6
36
6
12
12
12
0
6
0
0
% A
% Cys:
12
18
0
12
0
0
6
0
0
0
36
0
0
0
0
% C
% Asp:
6
0
12
0
42
6
0
0
0
0
0
6
6
0
0
% D
% Glu:
0
6
0
6
12
0
6
0
0
0
6
12
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
6
0
6
0
6
0
0
% F
% Gly:
0
0
0
6
6
18
0
0
0
0
0
0
18
0
6
% G
% His:
0
0
0
6
6
0
6
0
0
0
0
0
0
0
77
% H
% Ile:
6
0
12
0
0
0
0
6
0
0
6
6
0
0
0
% I
% Lys:
0
24
0
6
0
12
24
0
0
0
6
6
0
6
6
% K
% Leu:
18
0
0
0
0
6
6
18
24
42
6
0
6
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
12
12
6
0
0
6
0
6
0
6
0
0
% N
% Pro:
24
0
42
0
6
36
0
0
0
6
6
36
0
48
0
% P
% Gln:
0
24
12
24
0
6
0
0
0
0
0
12
24
0
0
% Q
% Arg:
0
12
6
18
0
0
0
12
0
12
12
0
6
6
0
% R
% Ser:
12
18
6
12
6
6
12
42
42
18
0
6
6
12
0
% S
% Thr:
18
0
6
0
0
0
0
12
12
6
0
6
0
18
6
% T
% Val:
0
0
6
0
6
0
6
6
0
6
0
12
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _