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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 25.15
Human Site: S58 Identified Species: 34.58
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S58 Q P Q D P A S S V C P Q P H Y
Chimpanzee Pan troglodytes XP_509678 958 109081 S58 Q P Q D P A S S L C P Q P H Y
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S58 Q P Q D P A S S L C P Q P H Y
Dog Lupus familis XP_542610 1186 133310 T89 K T G N P S T T P R V R L G Q
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 S58 Q P R D Q A S S L C P W P H Y
Rat Rattus norvegicus Q5U2P0 1054 120741 L51 C R N D G K L L S A E V T H Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 S65 R P R H P H S S L C P Q P H Y
Chicken Gallus gallus XP_417016 963 109342 S59 R P S G A A S S L C P G P H Y
Frog Xenopus laevis Q6GN11 1040 119148 L47 C P R D G K L L S E E L T H Y
Zebra Danio Brachydanio rerio A2RV18 1057 120333 L48 C Q N V G K V L S R D V T H Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 T56 S Q H A N K S T L F K F P H Y
Honey Bee Apis mellifera XP_397381 980 112421 F41 K V C E K C I F R I Q N P H Y
Nematode Worm Caenorhab. elegans Q17632 961 108768 N67 K I E N P V R N A K V G R H A
Sea Urchin Strong. purpuratus XP_787332 1412 160533 A175 S I Q E D L T A L N Q D L Y R
Poplar Tree Populus trichocarpa XP_002303419 935 105261 L47 E D K S K A R L T A T A S T I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 A44 K S C D S S A A R L S S S K I
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 S80 S D S P L E L S A P I G K H Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 93.3 93.3 6.6 N.A. 73.3 20 N.A. 66.6 60 26.6 13.3 N.A. 26.6 20 13.3 6.6
P-Site Similarity: 100 100 100 46.6 N.A. 86.6 20 N.A. 86.6 73.3 33.3 13.3 N.A. 40 33.3 40 40
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 20 N.A.
P-Site Similarity: 20 N.A. N.A. 33.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 6 6 36 6 12 12 12 0 6 0 0 6 % A
% Cys: 18 0 12 0 0 6 0 0 0 36 0 0 0 0 0 % C
% Asp: 0 12 0 42 6 0 0 0 0 0 6 6 0 0 0 % D
% Glu: 6 0 6 12 0 6 0 0 0 6 12 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 6 0 6 0 6 0 0 0 % F
% Gly: 0 0 6 6 18 0 0 0 0 0 0 18 0 6 0 % G
% His: 0 0 6 6 0 6 0 0 0 0 0 0 0 77 0 % H
% Ile: 0 12 0 0 0 0 6 0 0 6 6 0 0 0 12 % I
% Lys: 24 0 6 0 12 24 0 0 0 6 6 0 6 6 0 % K
% Leu: 0 0 0 0 6 6 18 24 42 6 0 6 12 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 12 12 6 0 0 6 0 6 0 6 0 0 0 % N
% Pro: 0 42 0 6 36 0 0 0 6 6 36 0 48 0 0 % P
% Gln: 24 12 24 0 6 0 0 0 0 0 12 24 0 0 6 % Q
% Arg: 12 6 18 0 0 0 12 0 12 12 0 6 6 0 6 % R
% Ser: 18 6 12 6 6 12 42 42 18 0 6 6 12 0 0 % S
% Thr: 0 6 0 0 0 0 12 12 6 0 6 0 18 6 0 % T
% Val: 0 6 0 6 0 6 6 0 6 0 12 12 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 71 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _