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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 32.42
Human Site: S609 Identified Species: 44.58
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S609 M N D D I T T S L R G L N K L
Chimpanzee Pan troglodytes XP_509678 958 109081 S609 M N D D I T T S L R G L N K L
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S599 M N D D I T T S L R G L N K L
Dog Lupus familis XP_542610 1186 133310 S837 M N D D I T T S L R G L N K L
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 S609 M N D D I T T S L R G L N Q L
Rat Rattus norvegicus Q5U2P0 1054 120741 P608 F S I V D D I P E F K T L E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 S617 M R D D I T T S L R G L N K L
Chicken Gallus gallus XP_417016 963 109342 S612 M N D D I T V S L R G L N K L
Frog Xenopus laevis Q6GN11 1040 119148 K602 L E P L S T E K E L H P L K Q
Zebra Danio Brachydanio rerio A2RV18 1057 120333 N603 E V E V P E L N P L K G S Q R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 S616 Q Q N E I A K S L R N L N R L
Honey Bee Apis mellifera XP_397381 980 112421 S584 Q Q D S L S K S L R N L N S L
Nematode Worm Caenorhab. elegans Q17632 961 108768 G621 E Q N D V A L G L R G L M K L
Sea Urchin Strong. purpuratus XP_787332 1412 160533 G1054 Q N D A L A I G L R G L L R M
Poplar Tree Populus trichocarpa XP_002303419 935 105261 D613 L V D P V T K D L R N M N A L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 D611 L T D S L T T D L R N M N T L
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 G673 Q N D E L T M G M R A L L K L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 100 N.A. 93.3 0 N.A. 93.3 93.3 13.3 0 N.A. 46.6 46.6 46.6 40
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 93.3 93.3 20 26.6 N.A. 66.6 60 60 60
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 40 N.A. N.A. 46.6 46.6 N.A.
P-Site Similarity: 60 N.A. N.A. 66.6 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 6 0 18 0 0 0 0 6 0 0 6 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 71 48 6 6 0 12 0 0 0 0 0 0 0 % D
% Glu: 12 6 6 12 0 6 6 0 12 0 0 0 0 6 6 % E
% Phe: 6 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 18 0 0 53 6 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % H
% Ile: 0 0 6 0 48 0 12 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 18 6 0 0 12 0 0 53 0 % K
% Leu: 18 0 0 6 24 0 12 0 77 12 0 71 24 0 77 % L
% Met: 42 0 0 0 0 0 6 0 6 0 0 12 6 0 6 % M
% Asn: 0 48 12 0 0 0 0 6 0 0 24 0 65 0 0 % N
% Pro: 0 0 6 6 6 0 0 6 6 0 0 6 0 0 0 % P
% Gln: 24 18 0 0 0 0 0 0 0 0 0 0 0 12 6 % Q
% Arg: 0 6 0 0 0 0 0 0 0 83 0 0 0 12 6 % R
% Ser: 0 6 0 12 6 6 0 53 0 0 0 0 6 6 0 % S
% Thr: 0 6 0 0 0 65 42 0 0 0 0 6 0 6 0 % T
% Val: 0 12 0 12 12 0 6 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _