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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 35.76
Human Site: S643 Identified Species: 49.17
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.19
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S643 E V R F H M D S E T H D P I D
Chimpanzee Pan troglodytes XP_509678 958 109081 S643 E V R F H M D S E T H D P I D
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S633 E V R F H M D S E T H D P I D
Dog Lupus familis XP_542610 1186 133310 S871 E V R F H M D S E T H D P I D
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 S643 E I R F H M D S E T H D P I D
Rat Rattus norvegicus Q5U2P0 1054 120741 D661 V E V R V Q L D D K K N I H D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 S651 E V R F H M D S E T H D P I D
Chicken Gallus gallus XP_417016 963 109342 S646 E V R F H M D S E T H D P I D
Frog Xenopus laevis Q6GN11 1040 119148 G653 V E V R V Q L G E K H S I D D
Zebra Danio Brachydanio rerio A2RV18 1057 120333 D653 V E V R A Q L D E E K N I T A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 S650 E I R F Q V D S E T H E P L E
Honey Bee Apis mellifera XP_397381 980 112421 C618 E I R F Q V D C E T H D P I D
Nematode Worm Caenorhab. elegans Q17632 961 108768 W655 E V R F D M D W E S R T P K K
Sea Urchin Strong. purpuratus XP_787332 1412 160533 S1088 E I R F S M D S E T H D P I E
Poplar Tree Populus trichocarpa XP_002303419 935 105261 E640 A L T L A S A E V K F Q I D T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 E638 A L T L A S A E V K F D I D P
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 K702 N L A S P E V K V H M D S E T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 100 N.A. 93.3 6.6 N.A. 100 100 20 6.6 N.A. 60 73.3 53.3 80
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 100 100 20 13.3 N.A. 93.3 86.6 60 93.3
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: 6.6 N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 6 0 18 0 12 0 0 0 0 0 0 0 6 % A
% Cys: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 6 0 65 12 6 0 0 65 0 18 59 % D
% Glu: 65 18 0 0 0 6 0 12 77 6 0 6 0 6 12 % E
% Phe: 0 0 0 65 0 0 0 0 0 0 12 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 42 0 0 0 0 6 65 0 0 6 0 % H
% Ile: 0 24 0 0 0 0 0 0 0 0 0 0 30 53 0 % I
% Lys: 0 0 0 0 0 0 0 6 0 24 12 0 0 6 6 % K
% Leu: 0 18 0 12 0 0 18 0 0 0 0 0 0 6 0 % L
% Met: 0 0 0 0 0 53 0 0 0 0 6 0 0 0 0 % M
% Asn: 6 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % N
% Pro: 0 0 0 0 6 0 0 0 0 0 0 0 65 0 6 % P
% Gln: 0 0 0 0 12 18 0 0 0 0 0 6 0 0 0 % Q
% Arg: 0 0 65 18 0 0 0 0 0 0 6 0 0 0 0 % R
% Ser: 0 0 0 6 6 12 0 53 0 6 0 6 6 0 0 % S
% Thr: 0 0 12 0 0 0 0 0 0 59 0 6 0 6 12 % T
% Val: 18 42 18 0 12 12 6 0 18 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _