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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 23.33
Human Site: S720 Identified Species: 32.08
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 S720 I K T D T A K S L A E S L D Q
Chimpanzee Pan troglodytes XP_509678 958 109081 S720 I K T D T A K S L A E S L D R
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 S710 I K T D T A K S L A E S L D R
Dog Lupus familis XP_542610 1186 133310 S948 I K T D T A K S L A D S L D R
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 S720 I K T D T A K S L A D S L D R
Rat Rattus norvegicus Q5U2P0 1054 120741 T738 I D T R S N K T L A D S L D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 A728 I K T D T A K A L A E S L D G
Chicken Gallus gallus XP_417016 963 109342 A723 I K T D S A K A L A E S L D K
Frog Xenopus laevis Q6GN11 1040 119148 A730 I D T R S N K A L A D S L D Q
Zebra Danio Brachydanio rerio A2RV18 1057 120333 A730 I D T R S N R A L A D S L E R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 E727 V D I N S G L E L S H S L D K
Honey Bee Apis mellifera XP_397381 980 112421 K695 I N V N S G K K L A E S L D N
Nematode Worm Caenorhab. elegans Q17632 961 108768 G732 I I V E S G K G L A D S L N R
Sea Urchin Strong. purpuratus XP_787332 1412 160533 A1165 L Q V D S G K A L A D S L D K
Poplar Tree Populus trichocarpa XP_002303419 935 105261 L717 A A A V G L N L D V T S S K A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 L715 A A A I G L T L D V S S S K A
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 S779 T R K N M S I S L E S S K A L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 93.3 93.3 86.6 N.A. 86.6 53.3 N.A. 86.6 80 60 40 N.A. 26.6 53.3 40 46.6
P-Site Similarity: 100 100 100 100 N.A. 100 73.3 N.A. 93.3 100 80 80 N.A. 60 66.6 73.3 86.6
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 20 N.A.
P-Site Similarity: 6.6 N.A. N.A. 6.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 12 12 0 0 42 0 30 0 77 0 0 0 6 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 24 0 48 0 0 0 0 12 0 42 0 0 71 0 % D
% Glu: 0 0 0 6 0 0 0 6 0 6 36 0 0 6 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 12 24 0 6 0 0 0 0 0 0 6 % G
% His: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % H
% Ile: 71 6 6 6 0 0 6 0 0 0 0 0 0 0 0 % I
% Lys: 0 42 6 0 0 0 71 6 0 0 0 0 6 12 18 % K
% Leu: 6 0 0 0 0 12 6 12 89 0 0 0 83 0 6 % L
% Met: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 6 0 18 0 18 6 0 0 0 0 0 0 6 6 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 12 % Q
% Arg: 0 6 0 18 0 0 6 0 0 0 0 0 0 0 36 % R
% Ser: 0 0 0 0 48 6 0 36 0 6 12 100 12 0 6 % S
% Thr: 6 0 59 0 36 0 6 6 0 0 6 0 0 0 0 % T
% Val: 6 0 18 6 0 0 0 0 0 12 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _