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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
47.58
Human Site:
S831
Identified Species:
65.42
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
S831
A
Q
Y
A
Q
R
A
S
V
A
F
H
T
Q
L
Chimpanzee
Pan troglodytes
XP_509678
958
109081
S831
A
Q
Y
A
Q
R
A
S
V
A
F
H
T
Q
L
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
S821
A
Q
Y
A
Q
R
A
S
V
A
F
H
T
Q
L
Dog
Lupus familis
XP_542610
1186
133310
S1059
A
Q
Y
A
Q
R
A
S
V
A
F
H
T
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
S831
A
Q
Y
A
Q
R
A
S
V
A
F
H
T
Q
L
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S854
A
Q
R
S
Q
K
Q
S
T
E
L
F
Q
C
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
S839
A
Q
Y
A
Q
R
A
S
V
A
F
H
T
Q
L
Chicken
Gallus gallus
XP_417016
963
109342
S834
A
Q
Y
A
Q
R
A
S
V
A
F
H
T
Q
L
Frog
Xenopus laevis
Q6GN11
1040
119148
S842
A
Q
Q
C
Q
K
Q
S
T
E
L
F
Q
C
M
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S846
A
Q
H
S
Q
K
Q
S
I
E
L
F
Q
C
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
S840
A
Q
Y
A
G
R
A
S
V
A
L
N
T
H
L
Honey Bee
Apis mellifera
XP_397381
980
112421
S808
A
Q
Y
A
S
R
A
S
I
A
L
N
T
H
L
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
S845
A
Q
Y
A
G
R
A
S
V
Q
L
N
V
V
R
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
S1278
A
Q
Y
A
G
R
A
S
V
D
L
H
T
Q
I
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
A819
R
P
Q
L
T
S
I
A
D
N
L
N
Y
R
H
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
A817
R
P
Q
L
T
S
V
A
D
N
L
N
Y
R
H
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
R882
N
K
M
D
M
I
C
R
N
I
N
R
K
H
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
100
100
N.A.
100
26.6
N.A.
100
100
26.6
26.6
N.A.
73.3
66.6
53.3
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
46.6
N.A.
100
100
40
60
N.A.
80
80
60
80
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
0
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
83
0
0
65
0
0
65
12
0
53
0
0
0
0
0
% A
% Cys:
0
0
0
6
0
0
6
0
0
0
0
0
0
18
0
% C
% Asp:
0
0
0
6
0
0
0
0
12
6
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
18
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
42
18
0
0
0
% F
% Gly:
0
0
0
0
18
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
6
0
0
0
0
0
0
0
0
48
0
18
12
% H
% Ile:
0
0
0
0
0
6
6
0
12
6
0
0
0
0
6
% I
% Lys:
0
6
0
0
0
18
0
0
0
0
0
0
6
0
0
% K
% Leu:
0
0
0
12
0
0
0
0
0
0
53
0
0
0
53
% L
% Met:
0
0
6
0
6
0
0
0
0
0
0
0
0
0
18
% M
% Asn:
6
0
0
0
0
0
0
0
6
12
6
30
0
0
0
% N
% Pro:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
83
18
0
59
0
18
0
0
6
0
0
18
48
0
% Q
% Arg:
12
0
6
0
0
65
0
6
0
0
0
6
0
12
12
% R
% Ser:
0
0
0
12
6
12
0
83
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
12
0
0
0
12
0
0
0
59
0
0
% T
% Val:
0
0
0
0
0
0
6
0
59
0
0
0
6
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
65
0
0
0
0
0
0
0
0
0
12
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _