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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
42.42
Human Site:
T131
Identified Species:
58.33
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
T131
T
N
E
H
H
R
E
T
Y
V
E
Q
E
Q
G
Chimpanzee
Pan troglodytes
XP_509678
958
109081
T131
T
N
E
H
H
R
E
T
Y
V
E
Q
E
Q
G
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
G128
T
Y
V
E
Q
E
Q
G
E
N
A
N
D
R
N
Dog
Lupus familis
XP_542610
1186
133310
T359
T
N
E
H
H
R
E
T
Y
V
E
Q
E
Q
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
T131
T
N
E
H
H
K
E
T
Y
I
E
Q
E
Q
G
Rat
Rattus norvegicus
Q5U2P0
1054
120741
C125
A
N
E
F
Q
Q
H
C
Y
L
P
R
E
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
T138
T
N
E
H
H
R
E
T
Y
V
E
Q
K
Q
G
Chicken
Gallus gallus
XP_417016
963
109342
T132
T
N
E
H
H
R
E
T
Y
I
Q
Q
E
Q
G
Frog
Xenopus laevis
Q6GN11
1040
119148
A121
S
N
E
F
Q
N
H
A
Y
L
P
R
E
M
G
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S122
A
N
E
F
Q
Q
Y
S
Y
C
P
R
E
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
T129
V
N
E
H
H
K
E
T
Y
A
D
R
E
P
D
Honey Bee
Apis mellifera
XP_397381
980
112421
T114
I
N
E
H
H
K
E
T
Y
I
E
R
N
P
G
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
E140
F
M
N
E
F
H
C
E
T
F
S
E
S
S
K
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
T256
T
N
E
H
H
R
D
T
Y
I
E
I
E
P
K
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
T120
S
N
E
F
H
R
D
T
Y
V
Q
I
M
A
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
T117
S
N
H
V
H
K
D
T
Y
V
Q
A
M
E
K
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
E154
V
F
H
N
E
F
S
E
H
T
F
V
E
R
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
6.6
100
N.A.
86.6
33.3
N.A.
93.3
86.6
33.3
33.3
N.A.
53.3
60
0
66.6
P-Site Similarity:
100
100
26.6
100
N.A.
100
60
N.A.
100
100
53.3
60
N.A.
73.3
80
6.6
80
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
53.3
N.A.
N.A.
33.3
6.6
N.A.
P-Site Similarity:
73.3
N.A.
N.A.
66.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
0
0
0
6
0
6
6
6
0
6
0
% A
% Cys:
0
0
0
0
0
0
6
6
0
6
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
18
0
0
0
6
0
6
0
6
% D
% Glu:
0
0
77
12
6
6
48
12
6
0
42
6
65
6
0
% E
% Phe:
6
6
0
24
6
6
0
0
0
6
6
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
65
% G
% His:
0
0
12
53
65
6
12
0
6
0
0
0
0
0
0
% H
% Ile:
6
0
0
0
0
0
0
0
0
24
0
12
0
0
0
% I
% Lys:
0
0
0
0
0
24
0
0
0
0
0
0
6
12
18
% K
% Leu:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
6
% L
% Met:
0
6
0
0
0
0
0
0
0
0
0
0
12
6
0
% M
% Asn:
0
83
6
6
0
6
0
0
0
6
0
6
6
0
6
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
18
0
0
18
0
% P
% Gln:
0
0
0
0
24
12
6
0
0
0
18
36
0
36
0
% Q
% Arg:
0
0
0
0
0
42
0
0
0
0
0
30
0
12
0
% R
% Ser:
18
0
0
0
0
0
6
6
0
0
6
0
6
6
0
% S
% Thr:
48
0
0
0
0
0
0
65
6
6
0
0
0
0
0
% T
% Val:
12
0
6
6
0
0
0
0
0
36
0
6
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
6
0
0
0
0
6
0
83
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _