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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
33.94
Human Site:
T175
Identified Species:
46.67
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
T175
Q
L
Q
V
I
F
I
T
N
D
R
R
N
K
E
Chimpanzee
Pan troglodytes
XP_509678
958
109081
T175
Q
L
Q
V
I
F
I
T
N
D
R
R
N
K
E
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
T165
H
L
Q
V
I
F
I
T
N
D
R
K
N
K
E
Dog
Lupus familis
XP_542610
1186
133310
T403
H
L
Q
V
I
F
I
T
N
D
R
K
N
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
T175
Q
L
Q
V
I
L
I
T
N
D
R
K
N
K
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
T164
R
M
P
I
V
M
V
T
E
D
E
E
A
I
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
I182
N
P
P
H
V
V
L
I
T
N
D
R
K
N
K
Chicken
Gallus gallus
XP_417016
963
109342
T178
D
I
Q
V
I
F
L
T
N
D
R
N
N
K
E
Frog
Xenopus laevis
Q6GN11
1040
119148
V165
M
V
T
E
D
E
S
V
I
G
K
Y
N
T
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
I160
G
L
Q
P
V
V
M
I
T
E
D
R
D
A
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
A173
E
F
E
R
S
G
K
A
A
T
R
V
V
L
L
Honey Bee
Apis mellifera
XP_397381
980
112421
T156
K
I
K
T
I
L
L
T
D
D
A
K
N
R
Q
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
E183
P
V
V
L
V
F
D
E
D
S
K
K
R
M
E
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
T296
P
I
K
I
V
L
L
T
N
D
I
D
N
R
E
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
N164
L
I
T
N
D
R
E
N
K
R
K
A
T
E
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
N161
L
V
T
N
D
R
E
N
K
R
K
A
T
E
E
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
T196
D
I
N
V
V
L
V
T
N
D
R
L
N
R
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
86.6
86.6
N.A.
86.6
13.3
N.A.
6.6
73.3
13.3
20
N.A.
6.6
26.6
13.3
33.3
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
53.3
N.A.
33.3
86.6
26.6
46.6
N.A.
20
80
53.3
73.3
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
46.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
6
6
0
6
12
6
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
0
0
18
0
6
0
12
59
12
6
6
0
0
% D
% Glu:
6
0
6
6
0
6
12
6
6
6
6
6
0
12
71
% E
% Phe:
0
6
0
0
0
36
0
0
0
0
0
0
0
0
0
% F
% Gly:
6
0
0
0
0
6
0
0
0
6
0
0
0
0
0
% G
% His:
12
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
30
0
12
42
0
30
12
6
0
6
0
0
6
6
% I
% Lys:
6
0
12
0
0
0
6
0
12
0
24
30
6
36
6
% K
% Leu:
12
36
0
6
0
24
24
0
0
0
0
6
0
6
6
% L
% Met:
6
6
0
0
0
6
6
0
0
0
0
0
0
6
0
% M
% Asn:
6
0
6
12
0
0
0
12
48
6
0
6
59
6
0
% N
% Pro:
12
6
12
6
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
18
0
42
0
0
0
0
0
0
0
0
0
0
0
12
% Q
% Arg:
6
0
0
6
0
12
0
0
0
12
48
24
6
18
0
% R
% Ser:
0
0
0
0
6
0
6
0
0
6
0
0
0
0
0
% S
% Thr:
0
0
18
6
0
0
0
59
12
6
0
0
12
6
0
% T
% Val:
0
18
6
42
36
12
12
6
0
0
0
6
6
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _