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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
36.97
Human Site:
T250
Identified Species:
50.83
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
T250
S
G
T
Y
L
Q
G
T
F
R
A
S
R
E
N
Chimpanzee
Pan troglodytes
XP_509678
958
109081
T250
S
G
T
Y
L
Q
G
T
F
R
A
S
R
E
N
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
T240
S
G
T
Y
L
Q
G
T
F
R
A
S
R
E
N
Dog
Lupus familis
XP_542610
1186
133310
T478
S
G
T
Y
L
Q
G
T
F
R
A
S
R
E
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
T250
S
G
S
Y
L
Q
G
T
F
R
A
S
R
E
N
Rat
Rattus norvegicus
Q5U2P0
1054
120741
I247
S
G
R
Y
I
Q
G
I
L
N
V
N
K
H
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
T258
S
G
I
Y
L
Q
G
T
F
R
A
S
R
E
N
Chicken
Gallus gallus
XP_417016
963
109342
T253
S
G
I
Y
L
Q
G
T
Y
R
A
S
R
E
N
Frog
Xenopus laevis
Q6GN11
1040
119148
Q260
L
E
S
F
V
R
L
Q
G
L
G
G
K
E
T
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
I241
S
G
R
Y
I
Q
G
I
L
S
V
N
K
H
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
T254
Q
N
K
L
L
Q
G
T
F
Q
A
S
R
E
N
Honey Bee
Apis mellifera
XP_397381
980
112421
T229
H
G
K
L
L
Q
G
T
F
I
A
S
K
E
N
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
N255
S
G
T
I
K
R
G
N
F
S
V
S
R
E
N
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
T381
Q
G
R
Y
K
K
G
T
F
K
A
S
R
E
N
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
K241
K
G
I
Y
H
Q
G
K
L
R
V
N
R
Y
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
K238
R
G
I
Y
H
Q
G
K
L
R
V
N
R
F
N
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
N277
N
G
V
L
Y
Q
G
N
I
Q
I
S
E
Y
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
100
100
N.A.
93.3
33.3
N.A.
93.3
86.6
6.6
33.3
N.A.
66.6
66.6
60
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
53.3
N.A.
93.3
93.3
40
53.3
N.A.
73.3
73.3
66.6
80
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
46.6
N.A.
N.A.
46.6
33.3
N.A.
P-Site Similarity:
53.3
N.A.
N.A.
53.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
59
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
6
0
0
0
0
0
0
0
0
0
0
6
71
0
% E
% Phe:
0
0
0
6
0
0
0
0
59
0
0
0
0
6
0
% F
% Gly:
0
89
0
0
0
0
95
0
6
0
6
6
0
0
0
% G
% His:
6
0
0
0
12
0
0
0
0
0
0
0
0
12
0
% H
% Ile:
0
0
24
6
12
0
0
12
6
6
6
0
0
0
0
% I
% Lys:
6
0
12
0
12
6
0
12
0
6
0
0
24
0
0
% K
% Leu:
6
0
0
18
53
0
6
0
24
6
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
6
6
0
0
0
0
0
12
0
6
0
24
0
0
83
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
0
0
0
0
83
0
6
0
12
0
0
0
0
0
% Q
% Arg:
6
0
18
0
0
12
0
0
0
53
0
0
71
0
12
% R
% Ser:
59
0
12
0
0
0
0
0
0
12
0
71
0
0
0
% S
% Thr:
0
0
30
0
0
0
0
59
0
0
0
0
0
0
6
% T
% Val:
0
0
6
0
6
0
0
0
0
0
30
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
71
6
0
0
0
6
0
0
0
0
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _