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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
23.03
Human Site:
T332
Identified Species:
31.67
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
T332
E
T
E
R
M
L
K
T
A
V
S
E
K
M
L
Chimpanzee
Pan troglodytes
XP_509678
958
109081
T332
E
R
E
R
M
L
K
T
A
V
S
E
K
M
L
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
T322
E
R
E
R
M
L
K
T
A
V
S
E
K
M
L
Dog
Lupus familis
XP_542610
1186
133310
T560
E
R
E
R
I
L
K
T
A
V
S
E
K
M
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
T332
E
R
E
L
L
L
K
T
A
V
S
E
K
M
L
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S326
K
A
S
G
E
S
P
S
E
P
M
P
T
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
T340
E
K
E
N
A
L
K
T
A
V
N
E
K
M
L
Chicken
Gallus gallus
XP_417016
963
109342
A335
E
K
E
N
I
L
K
A
S
V
N
K
N
M
L
Frog
Xenopus laevis
Q6GN11
1040
119148
A321
E
K
V
G
D
M
Q
A
E
V
M
P
T
G
R
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S320
R
P
L
E
D
T
Q
S
Q
P
M
P
T
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
A339
E
M
L
N
Q
V
R
A
A
A
L
S
A
E
R
Honey Bee
Apis mellifera
XP_397381
980
112421
I307
K
K
I
L
D
K
F
I
S
S
N
K
M
E
K
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
A341
D
E
N
D
E
P
K
A
K
K
S
K
K
M
T
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
S777
E
D
D
T
D
N
S
S
I
G
P
K
K
G
A
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
F330
I
P
V
S
S
S
T
F
D
T
N
P
V
S
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
G328
N
L
S
H
E
T
S
G
D
K
N
A
A
P
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
I379
L
L
A
K
D
A
M
I
A
Q
R
S
K
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
93.3
93.3
86.6
N.A.
80
0
N.A.
73.3
46.6
13.3
0
N.A.
13.3
0
26.6
13.3
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
86.6
13.3
N.A.
80
73.3
26.6
13.3
N.A.
26.6
26.6
40
33.3
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
0
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
6
0
6
6
0
24
48
6
0
6
12
0
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
6
6
6
6
30
0
0
0
12
0
0
0
0
0
0
% D
% Glu:
59
6
42
6
18
0
0
0
12
0
0
36
0
12
0
% E
% Phe:
0
0
0
0
0
0
6
6
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
12
0
0
0
6
0
6
0
0
0
24
0
% G
% His:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
6
0
6
0
12
0
0
12
6
0
0
0
0
0
6
% I
% Lys:
12
24
0
6
0
6
48
0
6
12
0
24
53
6
6
% K
% Leu:
6
12
12
12
6
42
0
0
0
0
6
0
0
0
42
% L
% Met:
0
6
0
0
18
6
6
0
0
0
18
0
6
48
0
% M
% Asn:
6
0
6
18
0
6
0
0
0
0
30
0
6
0
0
% N
% Pro:
0
12
0
0
0
6
6
0
0
12
6
24
0
6
0
% P
% Gln:
0
0
0
0
6
0
12
0
6
6
0
0
0
0
0
% Q
% Arg:
6
24
0
24
0
0
6
0
0
0
6
0
0
0
24
% R
% Ser:
0
0
12
6
6
12
12
18
12
6
36
12
0
6
6
% S
% Thr:
0
6
0
6
0
12
6
36
0
6
0
0
18
0
6
% T
% Val:
0
0
12
0
0
6
0
0
0
48
0
0
6
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _