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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 33.94
Human Site: T575 Identified Species: 46.67
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.19
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 T575 H N A E I L K T K F T K S V I
Chimpanzee Pan troglodytes XP_509678 958 109081 T575 H N A E I L K T K F T K S V I
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 T565 H N A E I L K T K F T K S V I
Dog Lupus familis XP_542610 1186 133310 V803 H D A E I L K V R F T K S V I
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 T575 H N A E I L K T R F T K S V I
Rat Rattus norvegicus Q5U2P0 1054 120741 K574 K T S Y E I K K V W Y G R T I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 T583 H N A E I L K T R F T K S A I
Chicken Gallus gallus XP_417016 963 109342 T578 Q K A E I L K T R F T K S I I
Frog Xenopus laevis Q6GN11 1040 119148 R568 C S T Y E I R R V W Y G R T I
Zebra Danio Brachydanio rerio A2RV18 1057 120333 S569 A E T L E V C S V W F G R T L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 K582 N E A N V L S K R F H K S V I
Honey Bee Apis mellifera XP_397381 980 112421 T550 E D A N I I N T R Y C K S I I
Nematode Worm Caenorhab. elegans Q17632 961 108768 V587 S S A D I Q S V K Y H K S L I
Sea Urchin Strong. purpuratus XP_787332 1412 160533 V1020 P G A E I V N V R F T K S I I
Poplar Tree Populus trichocarpa XP_002303419 935 105261 T579 P E A E I I S T K Y T K S V I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 T577 P D A E I I S T R F T K S I I
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 V639 D S A N I V N V N F M K S V I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 80 N.A. 93.3 13.3 N.A. 86.6 73.3 6.6 0 N.A. 46.6 40 40 53.3
P-Site Similarity: 100 100 100 93.3 N.A. 100 33.3 N.A. 93.3 86.6 33.3 26.6 N.A. 66.6 73.3 66.6 73.3
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 66.6 N.A. N.A. 60 46.6 N.A.
P-Site Similarity: 80 N.A. N.A. 86.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 83 0 0 0 0 0 0 0 0 0 0 6 0 % A
% Cys: 6 0 0 0 0 0 6 0 0 0 6 0 0 0 0 % C
% Asp: 6 18 0 6 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 6 18 0 59 18 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 65 6 0 0 0 0 % F
% Gly: 0 6 0 0 0 0 0 0 0 0 0 18 0 0 0 % G
% His: 36 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % H
% Ile: 0 0 0 0 77 30 0 0 0 0 0 0 0 24 95 % I
% Lys: 6 6 0 0 0 0 48 12 30 0 0 83 0 0 0 % K
% Leu: 0 0 0 6 0 48 0 0 0 0 0 0 0 6 6 % L
% Met: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % M
% Asn: 6 30 0 18 0 0 18 0 6 0 0 0 0 0 0 % N
% Pro: 18 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 6 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 6 6 48 0 0 0 18 0 0 % R
% Ser: 6 18 6 0 0 0 24 6 0 0 0 0 83 0 0 % S
% Thr: 0 6 12 0 0 0 0 53 0 0 59 0 0 18 0 % T
% Val: 0 0 0 0 6 18 0 24 18 0 0 0 0 48 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 18 0 0 0 0 0 % W
% Tyr: 0 0 0 12 0 0 0 0 0 18 12 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _