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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
24.55
Human Site:
T608
Identified Species:
33.75
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
T608
N
M
N
D
D
I
T
T
S
L
R
G
L
N
K
Chimpanzee
Pan troglodytes
XP_509678
958
109081
T608
N
M
N
D
D
I
T
T
S
L
R
G
L
N
K
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
T598
N
M
N
D
D
I
T
T
S
L
R
G
L
N
K
Dog
Lupus familis
XP_542610
1186
133310
T836
A
M
N
D
D
I
T
T
S
L
R
G
L
N
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
T608
A
M
N
D
D
I
T
T
S
L
R
G
L
N
Q
Rat
Rattus norvegicus
Q5U2P0
1054
120741
I607
N
F
S
I
V
D
D
I
P
E
F
K
T
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
T616
S
M
R
D
D
I
T
T
S
L
R
G
L
N
K
Chicken
Gallus gallus
XP_417016
963
109342
V611
A
M
N
D
D
I
T
V
S
L
R
G
L
N
K
Frog
Xenopus laevis
Q6GN11
1040
119148
E601
D
L
E
P
L
S
T
E
K
E
L
H
P
L
K
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
L602
E
E
V
E
V
P
E
L
N
P
L
K
G
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
K615
T
Q
Q
N
E
I
A
K
S
L
R
N
L
N
R
Honey Bee
Apis mellifera
XP_397381
980
112421
K583
F
Q
Q
D
S
L
S
K
S
L
R
N
L
N
S
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
L620
K
E
Q
N
D
V
A
L
G
L
R
G
L
M
K
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
I1053
S
Q
N
D
A
L
A
I
G
L
R
G
L
L
R
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
K612
R
L
V
D
P
V
T
K
D
L
R
N
M
N
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
T610
R
L
T
D
S
L
T
T
D
L
R
N
M
N
T
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
M672
T
Q
N
D
E
L
T
M
G
M
R
A
L
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
100
93.3
N.A.
86.6
6.6
N.A.
86.6
86.6
13.3
0
N.A.
40
40
40
40
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
20
N.A.
93.3
86.6
26.6
26.6
N.A.
60
53.3
53.3
60
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
33.3
N.A.
N.A.
40
40
N.A.
P-Site Similarity:
53.3
N.A.
N.A.
60
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
18
0
0
0
6
0
18
0
0
0
0
6
0
0
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
6
0
0
71
48
6
6
0
12
0
0
0
0
0
0
% D
% Glu:
6
12
6
6
12
0
6
6
0
12
0
0
0
0
6
% E
% Phe:
6
6
0
0
0
0
0
0
0
0
6
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
18
0
0
53
6
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% H
% Ile:
0
0
0
6
0
48
0
12
0
0
0
0
0
0
0
% I
% Lys:
6
0
0
0
0
0
0
18
6
0
0
12
0
0
53
% K
% Leu:
0
18
0
0
6
24
0
12
0
77
12
0
71
24
0
% L
% Met:
0
42
0
0
0
0
0
6
0
6
0
0
12
6
0
% M
% Asn:
24
0
48
12
0
0
0
0
6
0
0
24
0
65
0
% N
% Pro:
0
0
0
6
6
6
0
0
6
6
0
0
6
0
0
% P
% Gln:
0
24
18
0
0
0
0
0
0
0
0
0
0
0
12
% Q
% Arg:
12
0
6
0
0
0
0
0
0
0
83
0
0
0
12
% R
% Ser:
12
0
6
0
12
6
6
0
53
0
0
0
0
6
6
% S
% Thr:
12
0
6
0
0
0
65
42
0
0
0
0
6
0
6
% T
% Val:
0
0
12
0
12
12
0
6
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _