Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 33.94
Human Site: T631 Identified Species: 46.67
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 T631 R I E K G A L T L S S P E V R
Chimpanzee Pan troglodytes XP_509678 958 109081 T631 R I E K G A L T L S S P E V R
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 T621 R I E K G A L T L S S P E V R
Dog Lupus familis XP_542610 1186 133310 T859 R I E K G A L T L S S P E V R
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 T631 R I E K G A L T L S S P E I R
Rat Rattus norvegicus Q5U2P0 1054 120741 L649 K R D R C G A L E L E G V E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 T639 R I D K G A L T L S S P E V R
Chicken Gallus gallus XP_417016 963 109342 T634 R I D N G A L T L S S P E V R
Frog Xenopus laevis Q6GN11 1040 119148 L641 R R N M S G A L E L E G V E V
Zebra Danio Brachydanio rerio A2RV18 1057 120333 L641 Q R D K G G A L E L E G V E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 V638 R M D N G A L V L A S P E I R
Honey Bee Apis mellifera XP_397381 980 112421 V606 R L E N G A L V L A S P E I R
Nematode Worm Caenorhab. elegans Q17632 961 108768 T643 R T G N G A L T L A S S E V R
Sea Urchin Strong. purpuratus XP_787332 1412 160533 T1076 R T D N G A L T L A S S E I R
Poplar Tree Populus trichocarpa XP_002303419 935 105261 R628 A K I M R Q R R I H R G A L T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 R626 A K I M R Q R R I D R G A L T
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 E690 K L K Q K R L E A G A L N L A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 100 N.A. 93.3 0 N.A. 93.3 86.6 6.6 13.3 N.A. 60 66.6 66.6 60
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 100 93.3 6.6 26.6 N.A. 86.6 86.6 73.3 80
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 0 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 13.3 N.A. N.A. 13.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 0 0 65 18 0 6 24 6 0 12 0 6 % A
% Cys: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 36 0 0 0 0 0 0 6 0 0 0 0 0 % D
% Glu: 0 0 36 0 0 0 0 6 18 0 18 0 65 18 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 6 0 71 18 0 0 0 6 0 30 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % H
% Ile: 0 42 12 0 0 0 0 0 12 0 0 0 0 24 0 % I
% Lys: 12 12 6 42 6 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 12 0 0 0 0 71 18 65 18 0 6 0 18 0 % L
% Met: 0 6 0 18 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 6 30 0 0 0 0 0 0 0 0 6 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 53 0 0 0 % P
% Gln: 6 0 0 6 0 12 0 0 0 0 0 0 0 0 0 % Q
% Arg: 71 18 0 6 12 6 12 12 0 0 12 0 0 0 65 % R
% Ser: 0 0 0 0 6 0 0 0 0 42 65 12 0 0 0 % S
% Thr: 0 12 0 0 0 0 0 53 0 0 0 0 0 0 12 % T
% Val: 0 0 0 0 0 0 0 12 0 0 0 0 18 42 18 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _