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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 42.12
Human Site: T645 Identified Species: 57.92
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.19
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 T645 R F H M D S E T H D P I D L Q
Chimpanzee Pan troglodytes XP_509678 958 109081 T645 R F H M D S E T H D P I D L Q
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 T635 R F H M D S E T H D P I D L Q
Dog Lupus familis XP_542610 1186 133310 T873 R F H M D S E T H D P I D L Q
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 T645 R F H M D S E T H D P I D L Q
Rat Rattus norvegicus Q5U2P0 1054 120741 K663 V R V Q L D D K K N I H D L I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 T653 R F H M D S E T H D P I D L Q
Chicken Gallus gallus XP_417016 963 109342 T648 R F H M D S E T H D P I D L Q
Frog Xenopus laevis Q6GN11 1040 119148 K655 V R V Q L G E K H S I D D L V
Zebra Danio Brachydanio rerio A2RV18 1057 120333 E655 V R A Q L D E E K N I T A L V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 T652 R F Q V D S E T H E P L E V E
Honey Bee Apis mellifera XP_397381 980 112421 T620 R F Q V D C E T H D P I D I E
Nematode Worm Caenorhab. elegans Q17632 961 108768 S657 R F D M D W E S R T P K K V M
Sea Urchin Strong. purpuratus XP_787332 1412 160533 T1090 R F S M D S E T H D P I E V E
Poplar Tree Populus trichocarpa XP_002303419 935 105261 K642 T L A S A E V K F Q I D T E T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 K640 T L A S A E V K F D I D P E N
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 H704 A S P E V K V H M D S E T S D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. 100 100 26.6 13.3 N.A. 53.3 66.6 40 73.3
P-Site Similarity: 100 100 100 100 N.A. 100 26.6 N.A. 100 100 26.6 20 N.A. 93.3 86.6 53.3 93.3
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: 0 N.A. N.A. 6.6 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 18 0 12 0 0 0 0 0 0 0 6 0 0 % A
% Cys: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 6 0 65 12 6 0 0 65 0 18 59 0 6 % D
% Glu: 0 0 0 6 0 12 77 6 0 6 0 6 12 12 18 % E
% Phe: 0 65 0 0 0 0 0 0 12 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 42 0 0 0 0 6 65 0 0 6 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 30 53 0 6 6 % I
% Lys: 0 0 0 0 0 6 0 24 12 0 0 6 6 0 0 % K
% Leu: 0 12 0 0 18 0 0 0 0 0 0 6 0 59 0 % L
% Met: 0 0 0 53 0 0 0 0 6 0 0 0 0 0 6 % M
% Asn: 0 0 0 0 0 0 0 0 0 12 0 0 0 0 6 % N
% Pro: 0 0 6 0 0 0 0 0 0 0 65 0 6 0 0 % P
% Gln: 0 0 12 18 0 0 0 0 0 6 0 0 0 0 42 % Q
% Arg: 65 18 0 0 0 0 0 0 6 0 0 0 0 0 0 % R
% Ser: 0 6 6 12 0 53 0 6 0 6 6 0 0 6 0 % S
% Thr: 12 0 0 0 0 0 0 59 0 6 0 6 12 0 6 % T
% Val: 18 0 12 12 6 0 18 0 0 0 0 0 0 18 12 % V
% Trp: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _