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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 35.15
Human Site: T715 Identified Species: 48.33
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 T715 S R N L E I K T D T A K S L A
Chimpanzee Pan troglodytes XP_509678 958 109081 T715 S R N L E I K T D T A K S L A
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 T705 S R N L E I K T D T A K S L A
Dog Lupus familis XP_542610 1186 133310 T943 S K N L E I K T D T A K S L A
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 T715 S K N L Q I K T D T A K S L A
Rat Rattus norvegicus Q5U2P0 1054 120741 T733 A K G F F I D T R S N K T L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 T723 S K D L D I K T D T A K A L A
Chicken Gallus gallus XP_417016 963 109342 T718 S K N L E I K T D S A K A L A
Frog Xenopus laevis Q6GN11 1040 119148 T725 A R G F S I D T R S N K A L A
Zebra Danio Brachydanio rerio A2RV18 1057 120333 T725 A H G F S I D T R S N R A L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 I722 Y Q G F Q V D I N S G L E L S
Honey Bee Apis mellifera XP_397381 980 112421 V690 N Q G F I I N V N S G K K L A
Nematode Worm Caenorhab. elegans Q17632 961 108768 V727 H R G F E I I V E S G K G L A
Sea Urchin Strong. purpuratus XP_787332 1412 160533 V1160 T R G F E L Q V D S G K A L A
Poplar Tree Populus trichocarpa XP_002303419 935 105261 A712 P L L R T A A A V G L N L D V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 A710 P L L R T A A A I G L T L D V
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 K774 N E M L N T R K N M S I S L E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 93.3 N.A. 86.6 33.3 N.A. 73.3 80 40 26.6 N.A. 6.6 26.6 40 40
P-Site Similarity: 100 100 100 100 N.A. 100 60 N.A. 100 100 60 53.3 N.A. 46.6 53.3 53.3 73.3
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 0 N.A. N.A. 0 20 N.A.
P-Site Similarity: 0 N.A. N.A. 0 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 18 0 0 0 0 12 12 12 0 0 42 0 30 0 77 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 6 0 6 0 24 0 48 0 0 0 0 12 0 % D
% Glu: 0 6 0 0 42 0 0 0 6 0 0 0 6 0 6 % E
% Phe: 0 0 0 42 6 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 42 0 0 0 0 0 0 12 24 0 6 0 0 % G
% His: 6 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 6 71 6 6 6 0 0 6 0 0 0 % I
% Lys: 0 30 0 0 0 0 42 6 0 0 0 71 6 0 0 % K
% Leu: 0 12 12 48 0 6 0 0 0 0 12 6 12 89 0 % L
% Met: 0 0 6 0 0 0 0 0 0 6 0 0 0 0 0 % M
% Asn: 12 0 36 0 6 0 6 0 18 0 18 6 0 0 0 % N
% Pro: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 12 0 0 12 0 6 0 0 0 0 0 0 0 0 % Q
% Arg: 0 36 0 12 0 0 6 0 18 0 0 6 0 0 0 % R
% Ser: 42 0 0 0 12 0 0 0 0 48 6 0 36 0 6 % S
% Thr: 6 0 0 0 12 6 0 59 0 36 0 6 6 0 0 % T
% Val: 0 0 0 0 0 6 0 18 6 0 0 0 0 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _