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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 28.79
Human Site: T732 Identified Species: 39.58
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 T732 L D Q A E S P T F P Y L N T L
Chimpanzee Pan troglodytes XP_509678 958 109081 T732 L D R A E S P T F P Y L N T L
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 T722 L D R A E S P T F P Y L N T L
Dog Lupus familis XP_542610 1186 133310 T960 L D R A D S P T F P Y L N T L
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 D732 L D R A E S P D F P Y L N T L
Rat Rattus norvegicus Q5U2P0 1054 120741 S750 L D S A N D P S D P L V N K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 T740 L D G A E Y P T F P Y L N T L
Chicken Gallus gallus XP_417016 963 109342 D735 L D K A E S P D F P Y L N T L
Frog Xenopus laevis Q6GN11 1040 119148 S742 L D Q A H D P S D P L V N Q L
Zebra Danio Brachydanio rerio A2RV18 1057 120333 R742 L E R A V D P R D P L V N R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 D739 L D K C V K A D N P Y F N T M
Honey Bee Apis mellifera XP_397381 980 112421 S707 L D N C H K E S N P Y F N T M
Nematode Worm Caenorhab. elegans Q17632 961 108768 K744 L N R C V D K K N P M L N R L
Sea Urchin Strong. purpuratus XP_787332 1412 160533 S1177 L D K A N I P S I P F F N Q L
Poplar Tree Populus trichocarpa XP_002303419 935 105261 L729 S K A L A D S L D R A V G D D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 L727 S K A L A D S L D R A V G E D
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 D791 K A L A D S L D R C V D P E D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 93.3 93.3 86.6 N.A. 86.6 46.6 N.A. 86.6 86.6 53.3 40 N.A. 40 40 33.3 46.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 60 N.A. 86.6 93.3 66.6 60 N.A. 53.3 53.3 46.6 66.6
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 0 N.A. N.A. 0 13.3 N.A.
P-Site Similarity: 6.6 N.A. N.A. 6.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 12 71 12 0 6 0 0 0 12 0 0 0 0 % A
% Cys: 0 0 0 18 0 0 0 0 0 6 0 0 0 0 0 % C
% Asp: 0 71 0 0 12 36 0 24 30 0 0 6 0 6 18 % D
% Glu: 0 6 0 0 36 0 6 0 0 0 0 0 0 12 0 % E
% Phe: 0 0 0 0 0 0 0 0 42 0 6 18 0 0 0 % F
% Gly: 0 0 6 0 0 0 0 0 0 0 0 0 12 0 0 % G
% His: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 6 0 0 6 0 0 0 0 0 0 % I
% Lys: 6 12 18 0 0 12 6 6 0 0 0 0 0 6 0 % K
% Leu: 83 0 6 12 0 0 6 12 0 0 18 48 0 0 71 % L
% Met: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 12 % M
% Asn: 0 6 6 0 12 0 0 0 18 0 0 0 83 0 0 % N
% Pro: 0 0 0 0 0 0 65 0 0 83 0 0 6 0 0 % P
% Gln: 0 0 12 0 0 0 0 0 0 0 0 0 0 12 0 % Q
% Arg: 0 0 36 0 0 0 0 6 6 12 0 0 0 12 0 % R
% Ser: 12 0 6 0 0 42 12 24 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 30 0 0 0 0 0 53 0 % T
% Val: 0 0 0 0 18 0 0 0 0 0 6 30 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 6 0 0 0 0 53 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _