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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
30.61
Human Site:
T773
Identified Species:
42.08
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
T773
G
L
A
S
P
I
Y
T
H
F
T
S
P
I
R
Chimpanzee
Pan troglodytes
XP_509678
958
109081
T773
G
L
A
S
P
I
Y
T
H
F
T
S
P
I
R
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
T763
G
L
A
S
P
I
Y
T
H
F
T
S
P
I
R
Dog
Lupus familis
XP_542610
1186
133310
T1001
G
L
A
S
P
I
Y
T
H
F
T
S
P
I
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
T773
G
L
A
S
P
I
Y
T
H
F
T
S
P
I
R
Rat
Rattus norvegicus
Q5U2P0
1054
120741
K791
H
Y
G
L
A
L
D
K
Y
T
H
F
T
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
T781
G
L
A
S
P
I
Y
T
H
F
T
S
P
I
R
Chicken
Gallus gallus
XP_417016
963
109342
T776
G
L
A
S
P
I
Y
T
H
F
T
S
P
I
R
Frog
Xenopus laevis
Q6GN11
1040
119148
K783
H
Y
G
L
A
L
E
K
Y
T
H
F
T
S
P
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
R783
H
Y
G
L
A
L
A
R
Y
T
H
F
T
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
I780
H
Y
G
L
A
A
P
I
Y
T
H
F
T
S
P
Honey Bee
Apis mellifera
XP_397381
980
112421
I748
H
Y
G
L
A
S
P
I
Y
T
H
F
T
S
P
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
I785
H
F
G
L
A
C
A
I
Y
T
H
F
T
S
P
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
I1218
H
F
G
L
A
S
P
I
Y
T
H
F
T
S
P
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
Y770
S
P
P
E
F
L
H
Y
G
L
A
A
P
L
Y
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
Y768
S
P
P
E
Y
H
H
Y
G
L
A
A
P
L
Y
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
Y832
S
Y
P
D
F
R
H
Y
G
L
A
V
D
I
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
100
100
0
0
N.A.
0
0
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
100
100
13.3
13.3
N.A.
6.6
6.6
6.6
6.6
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
42
0
42
6
12
0
0
0
18
12
0
0
0
% A
% Cys:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
6
0
0
6
0
0
0
0
0
6
0
0
% D
% Glu:
0
0
0
12
0
0
6
0
0
0
0
0
0
0
0
% E
% Phe:
0
12
0
0
12
0
0
0
0
42
0
42
0
0
0
% F
% Gly:
42
0
42
0
0
0
0
0
18
0
0
0
0
0
0
% G
% His:
42
0
0
0
0
6
18
0
42
0
42
0
0
0
0
% H
% Ile:
0
0
0
0
0
42
0
24
0
0
0
0
0
48
0
% I
% Lys:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% K
% Leu:
0
42
0
42
0
24
0
0
0
18
0
0
0
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
12
18
0
42
0
18
0
0
0
0
0
53
0
42
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
6
0
6
0
0
0
0
0
0
42
% R
% Ser:
18
0
0
42
0
12
0
0
0
0
0
42
0
42
0
% S
% Thr:
0
0
0
0
0
0
0
42
0
42
42
0
42
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
36
0
0
6
0
42
18
42
0
0
0
0
0
18
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _